GSTM1
Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Belongs to the GST superfamily. Mu family. Liver (at protein level). 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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Protein type: EC 2.5.1.18; Other Amino Acids Metabolism - glutathione; Transferase; Xenobiotic Metabolism - drug metabolism - cytochrome P450; Xenobiotic Metabolism - metabolism by cytochrome P450 |
Chromosomal Location of human Ortholog: 1p13.3 |
Cellular Component:
cytoplasm; cytosol; intercellular bridge
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Molecular Function:
enzyme binding; glutathione binding; glutathione transferase activity; protein homodimerization activity
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Biological Process:
cellular detoxification of nitrogen compound; glutathione derivative biosynthetic process; glutathione metabolic process; hepoxilin biosynthetic process; nitrobenzene metabolic process; prostaglandin metabolic process; xenobiotic catabolic process
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Reference #:
P09488
(UniProtKB)
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Alt. Names/Synonyms: glutathione S-alkyltransferase; glutathione S-aralkyltransferase; glutathione S-aryltransferase; glutathione S-transferase M1; Glutathione S-transferase Mu 1; GST class-mu 1; GST HB subunit 4; GST1; GSTM1; GSTM1-1; GSTM1a-1a; GSTM1b-1b; GTH4; GTM1; H-B; HB subunit 4; MGC26563; MU; MU-1; S-(hydroxyalkyl)glutathione lyase
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Gene Symbols: GSTM1
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Molecular weight:
25,712 Da
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Basal Isoelectric point:
6.24
Predict pI for various phosphorylation states
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