Myb Transcriptional activator; DNA-binding protein that specifically recognize the sequence 5'-YAAC[GT]G-3'. Plays an important role in the control of proliferation and differentiation of hematopoietic progenitor cells. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Oncoprotein; Transcription factor
Chromosomal Location of human Ortholog: 6q23.3
Cellular Component:  cytosol; nuclear matrix; nucleoplasm; nucleus; RNA polymerase II transcription regulator complex
Molecular Function:  DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity, RNA polymerase II-specific; protein binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding
Biological Process:  cellular response to hydrogen peroxide; cellular response to retinoic acid; erythrocyte differentiation; mitotic cell cycle; myeloid cell development; negative regulation of DNA-templated transcription; negative regulation of hematopoietic progenitor cell differentiation; negative regulation of megakaryocyte differentiation; negative regulation of transcription by RNA polymerase II; positive regulation of collagen biosynthetic process; positive regulation of DNA-templated transcription; positive regulation of glial cell proliferation; positive regulation of hepatic stellate cell activation; positive regulation of hepatic stellate cell proliferation; positive regulation of miRNA transcription; positive regulation of neuron apoptotic process; positive regulation of smooth muscle cell proliferation; positive regulation of testosterone secretion; positive regulation of transcription by RNA polymerase II; positive regulation of transforming growth factor beta production; regulation of DNA-templated transcription; response to hypoxia; skeletal muscle cell proliferation; T-helper 2 cell differentiation
Reference #:  P10242 (UniProtKB)
Alt. Names/Synonyms: c-myb; c-myb protein (140 AA); c-myb10A_CDS; c-myb13A_CDS; c-myb14A_CDS; c-myb8B_CDS; c-myb_CDS; Cmyb; efg; MYB; MYB proto-oncogene, transcription factor; oncogene AMV; Proto-oncogene c-Myb; Transcriptional activator Myb; v-myb avian myeloblastosis viral oncogene homolog; v-myb myeloblastosis viral oncogene homolog (avian)
Gene Symbols: MYB
Molecular weight: 72,341 Da
Basal Isoelectric point: 6.35  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Myb

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein