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CETN2
Plays a fundamental role in microtubule organizing center structure and function. Required for centriole duplication and correct spindle formation. Has a role in regulating cytokinesis and genome stability via cooperation with CALM1 and CCP110. Involved in global genome nucleotide excision repair (GG-NER) by acting as component of the XPC complex. Cooperatively with RAD23B appears to stabilize XPC. In vitro, stimulates DNA binding of the XPC:RAD23B dimer. The XPC complex is proposed to represent the first factor bound at the sites of DNA damage and together with other core recognition factors, XPA, RPA and the TFIIH complex, is part of the pre-incision (or initial recognition) complex. The XPC complex recognizes a wide spectrum of damaged DNA characterized by distortions of the DNA helix such as single-stranded loops, mismatched bubbles or single-stranded overhangs. The orientation of XPC complex binding appears to be crucial for inducing a productive NER. XPC complex is proposed to recognize and to interact with unpaired bases on the undamaged DNA strand which is followed by recruitment of the TFIIH complex and subsequent scanning for lesions in the opposite strand in a 5'-to-3' direction by the NER machinery. Cyclobutane pyrimidine dimers (CPDs) which are formed upon UV-induced DNA damage esacpe detection by the XPC complex due to a low degree of structural perurbation. Instead they are detected by the UV-DDB complex which in turn recruits and cooperates with the XPC complex in the respective DNA repair. As a component of the TREX-2 complex, involved in the export of mRNAs to the cytoplasm through the nuclear pores. Belongs to the centrin family. Note: This description may include information from UniProtKB.
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| Protein type: Calcium-binding; Cell cycle regulation; DNA repair, damage |
| Chromosomal Location of human Ortholog: Xq28 |
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Cellular Component:
9+2 motile cilium; apical part of cell; centriole; centrosome; ciliary basal body; cytosol; nuclear pore nuclear basket; nucleoplasm; photoreceptor connecting cilium; transcription export complex 2; XPC complex
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Molecular Function:
calcium ion binding; G-protein beta/gamma-subunit complex binding; heterotrimeric G-protein binding; microtubule binding; protein binding
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Biological Process:
cell division; centriole replication; mitotic cell cycle; mRNA transport; nucleotide-excision repair; protein transport; regulation of cytokinesis; spermatogenesis
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Reference #:
P41208
(UniProtKB)
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Alt. Names/Synonyms: CALT; caltractin (20kD calcium-binding protein); Caltractin isoform 1; CEN2; centrin 2; centrin, EF-hand protein, 2; Centrin-2; CETN2
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Gene Symbols: CETN2
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Molecular weight:
19,738 Da
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Basal Isoelectric point:
4.91
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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