RGS20
Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds selectively to G(z)-alpha and G(alpha)-i2 subunits, accelerates their GTPase activity and regulates their signaling activities. The G(z)-alpha activity is inhibited by the phosphorylation and palmitoylation of the G-protein. Negatively regulates mu-opioid receptor-mediated activation of the G-proteins. Isoform 5 is expressed in brain at high levels in the caudate nucleus and temporal lobe. 6 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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Protein type: GAP; GAP, RGS |
Chromosomal Location of mouse Ortholog: 1|1 A1 |
Cellular Component:
cytoplasm; Golgi apparatus; membrane; nucleus; trans-Golgi network
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Molecular Function:
GTPase activator activity
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Biological Process:
G protein-coupled receptor signaling pathway; negative regulation of signal transduction
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Reference #:
Q9QZB1
(UniProtKB)
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Alt. Names/Synonyms: 2900073E09Rik; MGC151302; MGC151306; Regulator of G-protein signaling 20; Regulator of G-protein signaling Z1; Rgs; RGS20; Rgsz1
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Gene Symbols: Rgs20
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Molecular weight:
26,986 Da
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Basal Isoelectric point:
5.1
Predict pI for various phosphorylation states
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CST Pathways:
GPCR Signaling to MAPKs
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