nAChRG
After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Gamma/CHRNG sub-subfamily. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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Protein type: Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass |
Chromosomal Location of human Ortholog: 2q37.1 |
Cellular Component:
neuron projection; plasma membrane; postsynaptic membrane; synapse
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Molecular Function:
acetylcholine receptor activity; acetylcholine-gated monoatomic cation-selective channel activity; channel activity; protein binding
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Biological Process:
chemical synaptic transmission; excitatory postsynaptic potential; monoatomic ion transmembrane transport; muscle contraction; nervous system process; regulation of membrane potential; signal transduction; synaptic transmission, cholinergic
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Disease: Multiple Pterygium Syndrome, Escobar Variant; Multiple Pterygium Syndrome, Lethal Type
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Reference #:
P07510
(UniProtKB)
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Alt. Names/Synonyms: Acetylcholine receptor subunit gamma; acetylcholine receptor, muscle, gamma subunit; acetylcholine receptor, nicotinic, gamma (muscle); ACHG; ACHRG; cholinergic receptor nicotinic gamma subunit; cholinergic receptor, nicotinic gamma; cholinergic receptor, nicotinic, gamma; cholinergic receptor, nicotinic, gamma (muscle); cholinergic receptor, nicotinic, gamma polypeptide; CHRNG; MGC133376; nAChRG
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Gene Symbols: CHRNG
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Molecular weight:
57,883 Da
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Basal Isoelectric point:
5.86
Predict pI for various phosphorylation states
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CST Pathways:
Alzheimer's Disease
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