TSPO
Can bind protoporphyrin IX and may play a role in the transport of porphyrins and heme. Promotes the transport of cholesterol across mitochondrial membranes and may play a role in lipid metabolism, but its precise physiological role is controversial. It is apparently not required for steroid hormone biosynthesis. Was initially identified as peripheral-type benzodiazepine receptor; can also bind isoquinoline carboxamides. Belongs to the TspO/BZRP family. Found in many tissue types. Expressed at the highest levels under normal conditions in tissues that synthesize steroids. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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Protein type: Apoptosis; Membrane protein, integral; Membrane protein, multi-pass; Mitochondrial; Receptor, misc. |
Chromosomal Location of human Ortholog: 22q13.2 |
Cellular Component:
cytosol; endoplasmic reticulum; intracellular membrane-bounded organelle; mitochondrial outer membrane; mitochondrion
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Molecular Function:
androgen binding; benzodiazepine receptor activity; cholesterol binding; cholesterol transfer activity; protein binding; transmembrane transporter binding
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Biological Process:
adrenal gland development; behavioral response to pain; C21-steroid hormone biosynthetic process; cellular hypotonic response; cellular response to lipopolysaccharide; cellular response to zinc ion; chloride transport; cholesterol homeostasis; contact inhibition; glial cell migration; heme biosynthetic process; intermembrane lipid transfer; maintenance of protein location in mitochondrion; monoatomic anion transport; negative regulation of ATP metabolic process; negative regulation of autophagy of mitochondrion; negative regulation of corticosterone secretion; negative regulation of glial cell proliferation; negative regulation of nitric oxide biosynthetic process; negative regulation of protein ubiquitination; negative regulation of tumor necrosis factor production; peripheral nervous system axon regeneration; positive regulation of apoptotic process; positive regulation of calcium ion transport; positive regulation of glial cell proliferation; positive regulation of mitochondrial depolarization; positive regulation of reactive oxygen species metabolic process; protein targeting to mitochondrion; regulation of cell population proliferation; regulation of cholesterol transport; regulation of steroid biosynthetic process; response to acetylcholine; response to manganese ion; response to progesterone; response to testosterone; response to vitamin B1; response to xenobiotic stimulus; steroid metabolic process; sterol transport
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Reference #:
P30536
(UniProtKB)
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Alt. Names/Synonyms: benzodiazepine peripheral binding site; BPBS; BZRP; DBI; IBP; MBR; mDRC; Mitochondrial benzodiazepine receptor; PBR; PBS; peripheral benzodiazepine receptor; Peripheral-type benzodiazepine receptor; pk18; PKBS; PTBR; RP3-526I14.4; Translocator protein; translocator protein (18kDa); TSPO; TSPOA
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Gene Symbols: TSPO
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Molecular weight:
18,828 Da
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Basal Isoelectric point:
9.43
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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