ORC1L
Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. Belongs to the ORC1 family. Note: This description may include information from UniProtKB.
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Protein type: DNA-binding; Motility/polarity/chemotaxis |
Chromosomal Location of mouse Ortholog: 4|4 C7 |
Cellular Component:
chromosome, telomeric region; nuclear origin of replication recognition complex; nucleoplasm; nucleus; origin recognition complex
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Molecular Function:
ATP binding; ATP hydrolysis activity; chromatin binding; DNA binding; DNA replication origin binding; metal ion binding; nucleotide binding
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Biological Process:
DNA replication; DNA replication initiation; mitotic DNA replication checkpoint signaling; positive regulation of G0 to G1 transition; positive regulation of smooth muscle cell proliferation
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Reference #:
Q9Z1N2
(UniProtKB)
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Alt. Names/Synonyms: AA545195; MmOR; MmORC1; Orc1; Orc1l; Origin recognition complex subunit 1; origin recognition complex, subunit 1; origin recognition complex, subunit 1-like (S.cereviaiae); OTTMUSP00000008599
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Gene Symbols: Orc1
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Molecular weight:
95,103 Da
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Basal Isoelectric point:
9.23
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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