Mnk1 a CAM kinase of the MAPKKAPK family that can regulate translation. Following activation by MAP kinases, Mnk1 phosphorylates eIF4E at Ser209, increasing its affinity for the 7-methylguanosine-containing mRNA cap. Two MAPK phosphorylation sites in mouse Mnk1 (Thr197 and Thr202) are essential for its kinase activity. Three alternatively spliced human isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: CAMK group; EC 2.7.11.1; Kinase, protein; MAPKAPK family; MNK subfamily; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); Translation
Chromosomal Location of Human Ortholog: 4|4 D1
Cellular Component:  cytoplasm; nucleoplasm; nucleus
Molecular Function:  ATP binding; calcium-dependent protein serine/threonine kinase activity; calmodulin binding; calmodulin-dependent protein kinase activity; kinase activity; metal ion binding; nucleotide binding; protein kinase activity; protein serine/threonine kinase activity; transferase activity
Biological Process:  extrinsic apoptotic signaling pathway in absence of ligand; intracellular signal transduction; peptidyl-serine phosphorylation; phosphorylation; protein autophosphorylation; protein phosphorylation; regulation of translation; regulation of translational initiation; response to salt stress
Reference #:  O08605 (UniProtKB)
Alt. Names/Synonyms: 2410048M24Rik; MAP kinase signal-integrating kinase 1; MAP kinase-interacting serine/threonine kinase 1; MAP kinase-interacting serine/threonine-protein kinase 1; Mknk1; Mnk1; OTTMUSP00000009040
Gene Symbols: Mknk1
Molecular weight: 47,915 Da
Basal Isoelectric point: 6.54  Predict pI for various phosphorylation states
CST Pathways:  Angiogenesis  |  Growth And Differentiation Control by MAPKs  |  Phospholipase Signaling  |  Regulation of P38 MAPKs  |  Translation: eIF4E and p70S6K
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Mnk1

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  KinBase  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene