Hck Non-receptor tyrosine-protein kinase found in hematopoietic cells that transmits signals from cell surface receptors and plays an important role in the regulation of innate immune responses, including neutrophil, monocyte, macrophage and mast cell functions, phagocytosis, cell survival and proliferation, cell adhesion and migration. Acts downstream of receptors that bind the Fc region of immunoglobulins, such as FCGR1A and FCGR2A, but also CSF3R, PLAUR, the receptors for IFNG, IL2, IL6 and IL8, and integrins, such as ITGB1 and ITGB2. During the phagocytic process, mediates mobilization of secretory lysosomes, degranulation, and activation of NADPH oxidase to bring about the respiratory burst. Plays a role in the release of inflammatory molecules. Promotes reorganization of the actin cytoskeleton and actin polymerization, formation of podosomes and cell protrusions. Inhibits TP73-mediated transcription activation and TP73-mediated apoptosis. Phosphorylates CBL in response to activation of immunoglobulin gamma Fc region receptors. Phosphorylates ADAM15, BCR, ELMO1, FCGR2A, GAB1, GAB2, RAPGEF1, STAT5B, TP73, VAV1 and WAS. Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily. Detected in monocytes and neutrophils (at protein level). Expressed predominantly in cells of the myeloid and B-lymphoid lineages. Highly expressed in granulocytes. Detected in tonsil. 4 alternative splicing and alternative initiation human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor); Src family; TK group
Chromosomal Location of Human Ortholog: 2 H1|2 75.41 cM
Cellular Component:  caveola; cell junction; cell projection; cytoplasm; cytoplasmic vesicle; cytoskeleton; extrinsic component of cytoplasmic side of plasma membrane; focal adhesion; Golgi apparatus; lysosome; membrane; nucleoplasm; nucleus; plasma membrane
Molecular Function:  ATP binding; kinase activity; non-membrane spanning protein tyrosine kinase activity; nucleotide binding; phosphotyrosine residue binding; protein binding; protein kinase activity; protein tyrosine kinase activity; signaling receptor binding; transferase activity
Biological Process:  cell differentiation; defense response to Gram-positive bacterium; exocytosis; immune system process; inflammatory response; innate immune response; negative regulation of apoptotic process; peptidyl-tyrosine autophosphorylation; peptidyl-tyrosine phosphorylation; phagocytosis; phosphorylation; positive regulation of actin cytoskeleton reorganization; positive regulation of cell proliferation; protein autophosphorylation; protein phosphorylation; regulation of cell shape; regulation of DNA-binding transcription factor activity; regulation of phagocytosis; regulation of podosome assembly; transmembrane receptor protein tyrosine kinase signaling pathway
Reference #:  P08103 (UniProtKB)
Alt. Names/Synonyms: AI849071; B cell/myeloid kinase; B-cell/myeloid kinase; BMK; Hck; Hematopoietic cell kinase; Hemopoietic cell kinase; MGC18625; p56-HCK/p59-HCK; Tyrosine-protein kinase HCK
Gene Symbols: Hck
Molecular weight: 59,129 Da
Basal Isoelectric point: 6.82  Predict pI for various phosphorylation states
CST Pathways:  GPCR Signaling to MAPKs  |  Tyrosine Kinases & Substrates
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Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  KinBase  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene