Hck a protein-tyrosine kinase of the Src family that is predominantly expressed in hemopoietic cell types. The encoded protein may help couple the Fc receptor to the activation of the respiratory burst. In addition, it may play a role in neutrophil migration and in the degranulation of neutrophils. Alternate translation initiation site usage, including a non-AUG (CUG) codon, results in the production of two different isoforms that have different subcellular localization. Note: This description may include information from UniProtKB.
Protein type: EC; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor); Src family; TK group
Chromosomal Location of Human Ortholog: 2 H1|2 75.41 cM
Cellular Component:  actin filament; caveola; cell junction; cell projection; cytoplasm; cytoplasmic vesicle; cytoskeleton; extrinsic component of cytoplasmic side of plasma membrane; focal adhesion; Golgi apparatus; lysosome; membrane; nucleoplasm; nucleus; plasma membrane
Molecular Function:  ATP binding; kinase activity; non-membrane spanning protein tyrosine kinase activity; nucleotide binding; phosphotyrosine binding; protein binding; protein kinase activity; protein tyrosine kinase activity; receptor binding; transferase activity
Biological Process:  cell differentiation; defense response to Gram-positive bacterium; exocytosis; immune system process; inflammatory response; innate immune response; negative regulation of apoptosis; peptidyl-tyrosine autophosphorylation; peptidyl-tyrosine phosphorylation; phagocytosis; phosphorylation; positive regulation of actin cytoskeleton reorganization; positive regulation of cell proliferation; protein amino acid phosphorylation; protein autophosphorylation; regulation of cell proliferation; regulation of cell shape; regulation of phagocytosis; regulation of podosome assembly; regulation of transcription factor activity; transmembrane receptor protein tyrosine kinase signaling pathway
Reference #:  P08103 (UniProtKB)
Alt. Names/Synonyms: AI849071; B cell/myeloid kinase; B-cell/myeloid kinase; BMK; Hck; Hemopoietic cell kinase; MGC18625; p56-HCK/p59-HCK; Tyrosine-protein kinase HCK
Gene Symbols: Hck
Molecular weight: 59,129 Da
Basal Isoelectric point: 6.82  Predict pI for various phosphorylation states
CST Pathways:  GPCR Signaling to MAPKs  |  Tyrosine Kinases & Substrates
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Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  KinBase  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene