ING2 Seems to be involved in p53/TP53 activation and p53/TP53-dependent apoptotic pathways, probably by enhancing acetylation of p53/TP53. Component of a mSin3A-like corepressor complex, which is probably involved in deacetylation of nucleosomal histones. ING2 activity seems to be modulated by binding to phosphoinositides (PtdInsPs). Belongs to the ING family. Widely expressed. Higher expressed in colon-cancer tumor than in normal colon tissues. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: DNA-binding
Chromosomal Location of Human Ortholog: 4q35.1
Cellular Component:  CCAAT-binding factor complex; cytosol; Golgi apparatus; nucleoplasm; nucleus; plasma membrane; Sin3 complex
Molecular Function:  chromatin binding; DNA binding; metal ion binding; methylated histone binding; phosphatidylinositol binding; protein binding; protein-containing complex binding
Biological Process:  chromatin organization; flagellated sperm motility; male germ-line stem cell asymmetric division; male meiosis I; negative regulation of cell proliferation; negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; positive regulation of histone deacetylation; positive regulation of transcription, DNA-templated; positive regulation of transforming growth factor beta receptor signaling pathway; regulation of cellular senescence; regulation of growth; regulation of response to DNA damage stimulus; regulation of transcription, DNA-templated; seminiferous tubule development; signal transduction; spermatid development; spermatogenesis
Reference #:  Q9H160 (UniProtKB)
Alt. Names/Synonyms: ING1L; ING1Lp; ING2; Inhibitor of growth 1-like protein; inhibitor of growth family member 2; inhibitor of growth family, member 1-like; inhibitor of growth family, member 2; Inhibitor of growth protein 2; p32; p33ING2
Gene Symbols: ING2
Molecular weight: 32,808 Da
Basal Isoelectric point: 8.17  Predict pI for various phosphorylation states
CST Pathways:  Mitochondrial Control of Apoptosis
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene