JARID1D Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. May play a role in spermatogenesis. Involved in transcriptional repression of diverse metastasis-associated genes; in this function seems to cooperate with ZMYND8. Suppresses prostate cancer cell invasion. Regulates androgen receptor (AR) transcriptional activity by demethylating H3K4me3 active transcription marks. Belongs to the JARID1 histone demethylase family. Expression is highly down-regulated in metastatic prostate tumors. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC 1.14.11.-; Oxidoreductase
Chromosomal Location of Human Ortholog: Yq11.223
Cellular Component:  fibrillar center; nucleoplasm
Molecular Function:  androgen receptor binding; dioxygenase activity; DNA binding; DNA-binding transcription factor activity, RNA polymerase II-specific; histone demethylase activity (H3-K4 specific); metal ion binding; protein binding
Biological Process:  histone H3-K4 demethylation; histone H3-K4 demethylation, trimethyl-H3-K4-specific; oxidation-reduction process; regulation of androgen receptor signaling pathway; regulation of transcription by RNA polymerase II
Disease: Spermatogenic Failure, Y-linked, 2
Reference #:  Q9BY66 (UniProtKB)
Alt. Names/Synonyms: [histone H3]-trimethyl-L-lysine(4) demethylase 5D; epididymis secretory sperm binding protein; H-Y; Histocompatibility Y antigen; Histone demethylase JARID1D; HY; HYA; JARID1D; Jumonji, AT rich interactive domain 1D (RBP2-like); Jumonji/ARID domain-containing protein 1D; KDM5D; KIAA0234; lysine (K)-specific demethylase 5D; lysine demethylase 5D; Lysine-specific demethylase 5D; Protein SmcY; selected mouse cDNA on Y, human homolog of; SMC homolog, Y chromosome; SMCY; Smcy homolog, Y chromosome; Smcy homolog, Y-linked
Gene Symbols: KDM5D
Molecular weight: 174,073 Da
Basal Isoelectric point: 5.59  Predict pI for various phosphorylation states
CST Pathways:  Histone Methylation
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

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