TNNI3 Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. Binds to actin and tropomyosin. Interacts with TRIM63. Interacts with STK4/MST1. Belongs to the troponin I family. Note: This description may include information from UniProtKB.
Protein type: Actin-binding; Motility/polarity/chemotaxis; Motor
Chromosomal Location of Human Ortholog: 7 A1|7 2.61 cM
Cellular Component:  cardiac myofibril; cardiac Troponin complex; contractile fiber; cytoplasm; myofibril; sarcomere; troponin complex
Molecular Function:  actin binding; actin filament binding; calcium channel inhibitor activity; calcium-dependent protein binding; metal ion binding; protein domain specific binding; protein kinase binding; troponin C binding; troponin T binding
Biological Process:  cardiac muscle contraction; cellular calcium ion homeostasis; heart contraction; heart development; muscle contraction; negative regulation of ATPase activity; regulation of cardiac muscle contraction by calcium ion signaling; regulation of muscle contraction; regulation of smooth muscle contraction; regulation of systemic arterial blood pressure by ischemic conditions; skeletal muscle contraction; striated muscle contraction; vasculogenesis; ventricular cardiac muscle tissue morphogenesis
Reference #:  P48787 (UniProtKB)
Alt. Names/Synonyms: Cardiac troponin I; cTnI; Tn1; Tnni3; troponin I, cardiac 3; Troponin I, cardiac muscle
Gene Symbols: Tnni3
Molecular weight: 24,259 Da
Basal Isoelectric point: 9.57  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene