STX1A a type IV membrane protein involved in docking of synaptic vesicles at presynaptic active zones. May play a critical role in neurotransmitter exocytosis. Part of the SNARE core complex containing SNAP25, VAMP2 and STX1A. Three splice variant isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Vesicle
Chromosomal Location of Human Ortholog: 7q11.23
Cellular Component:  actomyosin; axon; cell junction; cytosol; extracellular region; glutamatergic synapse; integral component of presynaptic membrane; integral component of synaptic vesicle membrane; neuron projection; nuclear membrane; plasma membrane; postsynaptic density; secretory granule; SNARE complex; synaptobrevin 2-SNAP-25-syntaxin-1a complex; synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex; synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex
Molecular Function:  ATP-dependent protein binding; calcium channel inhibitor activity; calcium-dependent protein binding; chloride channel inhibitor activity; ion channel binding; kinase binding; myosin head/neck binding; protein binding; protein binding, bridging; protein domain specific binding; protein heterodimerization activity; protein N-terminus binding
Biological Process:  cytokine-mediated signaling pathway; glutamate secretion; insulin secretion; neurotransmitter secretion; positive regulation of calcium ion-dependent exocytosis; positive regulation of catecholamine secretion; positive regulation of excitatory postsynaptic potential; positive regulation of neurotransmitter secretion; positive regulation of norepinephrine secretion; protein localization to membrane; protein sumoylation; regulation of insulin secretion; regulation of synaptic vesicle priming; response to gravity; secretion by cell; SNARE complex assembly; synaptic vesicle docking; synaptic vesicle endocytosis; synaptic vesicle exocytosis
Reference #:  Q16623 (UniProtKB)
Alt. Names/Synonyms: HPC-1; Neuron-specific antigen HPC-1; P35-1; STX1; STX1A; SYN1A; syntaxin 1A (brain); Syntaxin-1A
Gene Symbols: STX1A
Molecular weight: 33,023 Da
Basal Isoelectric point: 5.14  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB  |  Ensembl Protein