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RMND5B
Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1. MAEA and RMND5A are both required for catalytic activity of the CTLH E3 ubiquitin-protein ligase complex. Catalytic activity of the complex is required for normal cell proliferation. The CTLH E3 ubiquitin-protein ligase complex is not required for the degradation of enzymes involved in gluconeogenesis, such as FBP1. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Ubiquitin conjugating system; Ubiquitin ligase; Unknown function |
| Chromosomal Location of human Ortholog: 5q35.3 |
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Cellular Component:
cytoplasm; cytosol; GID complex; nucleus
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Molecular Function:
metal ion binding; protein binding; ubiquitin protein ligase activity; ubiquitin-protein transferase activity
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Biological Process:
proteasome-mediated ubiquitin-dependent protein catabolic process
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Reference #:
Q96G75
(UniProtKB)
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Alt. Names/Synonyms: DKFZp434K0926; E3 ubiquitin-protein transferase RMND5B; FLJ22318; GID complex subunit 2 homolog B; GID2; GID2B; Protein RMD5 homolog B; required for meiotic nuclear division 5 homolog B; required for meiotic nuclear division 5 homolog B (S. cerevisiae); RMD5B; RMND5B
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Gene Symbols: RMND5B
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Molecular weight:
44,414 Da
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Basal Isoelectric point:
6.15
Predict pI for various phosphorylation states
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