Hck Non-receptor tyrosine-protein kinase found in hematopoietic cells that transmits signals from cell surface receptors and plays an important role in the regulation of innate immune responses, including neutrophil, monocyte, macrophage and mast cell functions, phagocytosis, cell survival and proliferation, cell adhesion and migration. Acts downstream of receptors that bind the Fc region of immunoglobulins, such as FCGR1A and FCGR2A, but also CSF3R, PLAUR, the receptors for IFNG, IL2, IL6 and IL8, and integrins, such as ITGB1 and ITGB2. During the phagocytic process, mediates mobilization of secretory lysosomes, degranulation, and activation of NADPH oxidase to bring about the respiratory burst. Plays a role in the release of inflammatory molecules. Promotes reorganization of the actin cytoskeleton and actin polymerization, formation of podosomes and cell protrusions. Inhibits TP73-mediated transcription activation and TP73-mediated apoptosis. Phosphorylates CBL in response to activation of immunoglobulin gamma Fc region receptors. Phosphorylates ADAM15, BCR, ELMO1, FCGR2A, GAB1, GAB2, RAPGEF1, STAT5B, TP73, VAV1 and WAS. Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily. Detected in monocytes and neutrophils (at protein level). Expressed predominantly in cells of the myeloid and B-lymphoid lineages. Highly expressed in granulocytes. Detected in tonsil. 4 alternative splicing and alternative initiation human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor); Src family; TK group
Chromosomal Location of Human Ortholog: 20q11.21
Cellular Component:  caveola; cell projection; cytosol; extrinsic component of cytoplasmic side of plasma membrane; focal adhesion; Golgi apparatus; lysosome; nucleoplasm; plasma membrane; transport vesicle
Molecular Function:  ATP binding; phosphotyrosine residue binding; protein binding; protein tyrosine kinase activity
Biological Process:  cell adhesion; cytokine-mediated signaling pathway; Fc-gamma receptor signaling pathway involved in phagocytosis; inflammatory response; innate immune response-activating signal transduction; integrin-mediated signaling pathway; interferon-gamma-mediated signaling pathway; leukocyte degranulation; leukocyte migration involved in immune response; lipopolysaccharide-mediated signaling pathway; mesoderm development; negative regulation of apoptotic process; peptidyl-tyrosine phosphorylation; positive regulation of actin cytoskeleton reorganization; positive regulation of actin filament polymerization; positive regulation of cell proliferation; protein autophosphorylation; protein phosphorylation; regulation of cell shape; regulation of defense response to virus by virus; regulation of DNA-binding transcription factor activity; regulation of inflammatory response; regulation of phagocytosis; regulation of podosome assembly; respiratory burst after phagocytosis
Reference #:  P08631 (UniProtKB)
Alt. Names/Synonyms: HCK; Hemopoietic cell kinase; JTK9; p59-HCK/p60-HCK; Tyrosine-protein kinase HCK
Gene Symbols: HCK
Molecular weight: 59,600 Da
Basal Isoelectric point: 6.27  Predict pI for various phosphorylation states
CST Pathways:  GPCR Signaling to MAPKs  |  Tyrosine Kinases & Substrates
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  KinBase  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene