EphB3 Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Generally has an overlapping and redundant function with EPHB2. Like EPHB2, functions in axon guidance during development regulating for instance the neurons forming the corpus callosum and the anterior commissure, 2 major interhemispheric connections between the temporal lobes of the cerebral cortex. In addition to its role in axon guidance plays also an important redundant role with other ephrin-B receptors in development and maturation of dendritic spines and the formation of excitatory synapses. Controls other aspects of development through regulation of cell migration and positioning. This includes angiogenesis, palate development and thymic epithelium development for instance. Forward and reverse signaling through the EFNB2/EPHB3 complex also regulate migration and adhesion of cells that tubularize the urethra and septate the cloaca. Finally, plays an important role in intestinal epithelium differentiation segregating progenitor from differentiated cells in the crypt. Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily. Ubiquitous. Note: This description may include information from UniProtKB.
Protein type: EC; Eph family; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor); TK group
Chromosomal Location of Human Ortholog: 3q27.1
Cellular Component:  cytosol; dendrite; extracellular region; integral component of plasma membrane; plasma membrane
Molecular Function:  ATP binding; axon guidance receptor activity; ephrin receptor activity
Biological Process:  angiogenesis; axon guidance; axonal fasciculation; cell migration; central nervous system projection neuron axonogenesis; corpus callosum development; dendritic spine development; dendritic spine morphogenesis; digestive tract morphogenesis; ephrin receptor signaling pathway; peptidyl-tyrosine phosphorylation; positive regulation of synapse assembly; protein autophosphorylation; regulation of axonogenesis; regulation of cell-cell adhesion; regulation of GTPase activity; retinal ganglion cell axon guidance; roof of mouth development; substrate adhesion-dependent cell spreading; thymus development; urogenital system development
Reference #:  P54753 (UniProtKB)
Alt. Names/Synonyms: EK2; Embryonic kinase 2; EPH receptor B3; EPH-like kinase 2; EPH-like tyrosine kinase 2; EPH-like tyrosine kinase-2; EPHB3; Ephrin type-B receptor 3; ETK2; HEK2; human embryo kinase 2; TYRO6; Tyrosine-protein kinase TYRO6
Gene Symbols: EPHB3
Molecular weight: 110,330 Da
Basal Isoelectric point: 5.95  Predict pI for various phosphorylation states
CST Pathways:  Tyrosine Kinases & Substrates
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  KinBase  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene