FZD5 Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK- 3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Interacts specifically with Wnt5A to induce the beta- catenin pathway. Interacts with GOPC. Belongs to the G-protein coupled receptor Fz/Smo family. Note: This description may include information from UniProtKB.
Protein type: GPCR, Fz/Smo family; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR
Chromosomal Location of Human Ortholog: 2q33.3
Cellular Component:  axon; bicellular tight junction; cell surface; clathrin-coated endocytic vesicle membrane; dendrite; early endosome membrane; Golgi membrane; integral component of plasma membrane; perikaryon; perinuclear region of cytoplasm; plasma membrane; synapse
Molecular Function:  amyloid-beta binding; G protein-coupled receptor activity; lipid binding; protein binding; protein kinase binding; protein-containing complex binding; ubiquitin protein ligase binding; Wnt-activated receptor activity; Wnt-protein binding
Biological Process:  angiogenesis; anterior/posterior axis specification, embryo; apoptotic process involved in morphogenesis; beta-catenin destruction complex disassembly; branching involved in labyrinthine layer morphogenesis; canonical Wnt signaling pathway; cell maturation; cellular response to molecule of bacterial origin; chorionic trophoblast cell differentiation; embryonic axis specification; embryonic camera-type eye morphogenesis; G protein-coupled receptor signaling pathway; labyrinthine layer blood vessel development; negative regulation of cell proliferation; neuron differentiation; positive regulation of interferon-gamma production; positive regulation of interleukin-1 beta secretion; positive regulation of JUN kinase activity; positive regulation of T cell cytokine production; positive regulation of transcription by RNA polymerase II; positive regulation of tumor necrosis factor secretion; post-embryonic camera-type eye development; regulation of bicellular tight junction assembly; regulation of chorionic trophoblast cell proliferation; Spemann organizer formation; synapse assembly; syncytiotrophoblast cell differentiation involved in labyrinthine layer development; T cell differentiation in thymus; Wnt signaling pathway, calcium modulating pathway; Wnt signaling pathway, planar cell polarity pathway
Reference #:  Q13467 (UniProtKB)
Alt. Names/Synonyms: C2orf31; DKFZp434E2135; frizzled homolog 5 (Drosophila); Frizzled-5; Fz-5; FZD5; FzE5; hFz5; MGC129692; seven-transmembrane receptor frizzled-5; Wnt receptor
Gene Symbols: FZD5
Molecular weight: 64,507 Da
Basal Isoelectric point: 8.69  Predict pI for various phosphorylation states
CST Pathways:  ESC Pluripotency and Differentiation  |  mTOR Signaling  |  Translation: eIF4E and p70S6K  |  Wnt/ß-Catenin Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene