CSK Non-receptor tyrosine-protein kinase that plays an important role in the regulation of cell growth, differentiation, migration and immune response. Phosphorylates tyrosine residues located in the C-terminal tails of Src-family kinases (SFKs) including LCK, SRC, HCK, FYN, LYN, CSK or YES1. Upon tail phosphorylation, Src-family members engage in intramolecular interactions between the phosphotyrosine tail and the SH2 domain that result in an inactive conformation. To inhibit SFKs, CSK is recruited to the plasma membrane via binding to transmembrane proteins or adapter proteins located near the plasma membrane. Suppresses signaling by various surface receptors, including T-cell receptor (TCR) and B-cell receptor (BCR) by phosphorylating and maintaining inactive several positive effectors such as FYN or LCK. Belongs to the protein kinase superfamily. Tyr protein kinase family. CSK subfamily. Expressed in lung and macrophages. Note: This description may include information from UniProtKB.
Protein type: Csk family; EC; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor); TK group
Chromosomal Location of human Ortholog: 15q24.1
Cellular Component:  cell-cell junction; cytoplasm; cytosol; membrane raft; plasma membrane
Molecular Function:  ATP binding; identical protein binding; metal ion binding; non-membrane spanning protein tyrosine kinase activity; proline-rich region binding; protein binding; protein C-terminus binding; protein kinase A catalytic subunit binding; protein phosphatase binding; protein tyrosine kinase activity
Biological Process:  adaptive immune response; brain development; cellular response to peptide hormone stimulus; negative regulation of bone resorption; negative regulation of cell proliferation; negative regulation of ERK1 and ERK2 cascade; negative regulation of Golgi to plasma membrane protein transport; negative regulation of interleukin-6 production; negative regulation of kinase activity; negative regulation of low-density lipoprotein particle clearance; negative regulation of phagocytosis; oligodendrocyte differentiation; peptidyl-tyrosine phosphorylation; positive regulation of MAP kinase activity; protein autophosphorylation; protein phosphorylation; T cell costimulation; T cell receptor signaling pathway
Reference #:  P41240 (UniProtKB)
Alt. Names/Synonyms: C-Src kinase; c-src tyrosine kinase; C-terminal Src kinase; CSK; CSK, non-receptor tyrosine kinase; MGC117393; Protein-tyrosine kinase CYL; Tyrosine-protein kinase CSK
Gene Symbols: CSK
Molecular weight: 50,704 Da
Basal Isoelectric point: 6.62  Predict pI for various phosphorylation states
CST Pathways:  B Cell Receptor Signaling  |  Tyrosine Kinases & Substrates
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  KinBase  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB  |  Ensembl Protein