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CSK
Non-receptor tyrosine-protein kinase that plays an important role in the regulation of cell growth, differentiation, migration and immune response. Phosphorylates tyrosine residues located in the C-terminal tails of Src-family kinases (SFKs) including LCK, SRC, HCK, FYN, LYN, CSK or YES1. Upon tail phosphorylation, Src-family members engage in intramolecular interactions between the phosphotyrosine tail and the SH2 domain that result in an inactive conformation. To inhibit SFKs, CSK is recruited to the plasma membrane via binding to transmembrane proteins or adapter proteins located near the plasma membrane. Suppresses signaling by various surface receptors, including T-cell receptor (TCR) and B-cell receptor (BCR) by phosphorylating and maintaining inactive several positive effectors such as FYN or LCK. Belongs to the protein kinase superfamily. Tyr protein kinase family. CSK subfamily. Expressed in lung and macrophages. Note: This description may include information from UniProtKB.
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| Protein type: Csk family; EC 2.7.10.2; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor); TK group |
| Chromosomal Location of human Ortholog: 15q24.1 |
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Cellular Component:
cell-cell junction; cytoplasm; cytosol; plasma membrane
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Molecular Function:
ATP binding; identical protein binding; metal ion binding; non-membrane spanning protein tyrosine kinase activity; proline-rich region binding; protein binding; protein kinase A catalytic subunit binding; protein phosphatase binding; protein tyrosine kinase activity; protein tyrosine kinase binding
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Biological Process:
adaptive immune response; adherens junction organization; cellular response to peptide hormone stimulus; negative regulation of bone resorption; negative regulation of cell population proliferation; negative regulation of ERK1 and ERK2 cascade; negative regulation of Golgi to plasma membrane protein transport; negative regulation of interleukin-6 production; negative regulation of kinase activity; negative regulation of low-density lipoprotein particle clearance; negative regulation of phagocytosis; oligodendrocyte differentiation; positive regulation of MAP kinase activity; protein autophosphorylation; protein phosphorylation; regulation of Fc receptor mediated stimulatory signaling pathway; T cell costimulation; T cell receptor signaling pathway
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Reference #:
P41240
(UniProtKB)
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Alt. Names/Synonyms: C-Src kinase; c-src tyrosine kinase; C-terminal Src kinase; CSK; CSK, non-receptor tyrosine kinase; MGC117393; Protein-tyrosine kinase CYL; Tyrosine-protein kinase CSK
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Gene Symbols: CSK
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Molecular weight:
50,704 Da
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Basal Isoelectric point:
6.62
Predict pI for various phosphorylation states
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CST Pathways:
B Cell Receptor Signaling
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Tyrosine Kinases & Substrates
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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