PHF5A Acts as a transcriptional regulator by binding to the GJA1/Cx43 promoter and enhancing its up-regulation by ESR1/ER- alpha. Also involved in pre-mRNA splicing. Belongs to the PHF5 family. Note: This description may include information from UniProtKB.
Protein type: RNA splicing; RNA-binding
Chromosomal Location of Human Ortholog: 15|15 E1
Cellular Component:  nuclear matrix; nuclear speck; nucleolus; nucleoplasm; nucleus; snRNP U2; spliceosomal complex; U12-type spliceosomal complex
Molecular Function:  DNA binding; DNA binding transcription factor activity; metal ion binding; protein binding; RNA binding
Biological Process:  mRNA processing; mRNA splicing, via spliceosome; positive regulation of transcription, DNA-templated; regulation of transcription, DNA-templated; RNA splicing; transcription, DNA-dependent
Reference #:  P83870 (UniProtKB)
Alt. Names/Synonyms: 1110007B08Rik; PHD finger protein 5A; PHD finger-like domain protein 5A; PHD finger-like domain-containing protein 5A; Phf5a; SF3b14b; Splicing factor 3B-associated 14 kDa protein
Gene Symbols: Phf5a
Molecular weight: 12,405 Da
Basal Isoelectric point: 8.78  Predict pI for various phosphorylation states
Select Structure to View Below

PHF5A

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene