NDUFS7 Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Belongs to the complex I 20 kDa subunit family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC 1.6.5.3; EC 1.6.99.3; Energy Metabolism - oxidative phosphorylation; Mitochondrial; Oxidoreductase
Chromosomal Location of Human Ortholog: 19p13.3
Cellular Component:  mitochondrial matrix; mitochondrial respiratory chain complex I; neuron projection; neuronal cell body; synaptic membrane
Molecular Function:  4 iron, 4 sulfur cluster binding; metal ion binding; NADH dehydrogenase (ubiquinone) activity; oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor; protease binding; protein binding; quinone binding
Biological Process:  mitochondrial electron transport, NADH to ubiquinone; mitochondrial respiratory chain complex I assembly
Disease: Mitochondrial Complex I Deficiency, Nuclear Type 3
Reference #:  O75251 (UniProtKB)
Alt. Names/Synonyms: CI-20; CI-20kD; complex I 20kDa subunit; complex I, mitochondrial respiratory chain, 20-KD subunit; Complex I-20kD; FLJ45860; FLJ46880; MC1DN3; MGC120002; MY017; NADH dehydrogenase (ubiquinone) Fe-S protein 7, 20kDa (NADH-coenzyme Q reductase); NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial; NADH-coenzyme Q reductase; NADH-ubiquinone oxidoreductase 20 kDa subunit; NADH:ubiquinone oxidoreductase core subunit S7; NADH:ubiquinone oxidoreductase PSST subunit; NDUFS7; NDUS7; PSST; PSST subunit
Gene Symbols: NDUFS7
Molecular weight: 23,564 Da
Basal Isoelectric point: 10.02  Predict pI for various phosphorylation states
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NDUFS7

Protein Structure Not Found.


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