MORG1
Molecular scaffold protein for various multimeric protein complexes. Acts as a module in the assembly of a multicomponent scaffold for the ERK pathway, linking ERK responses to specific agonists. At low concentrations it enhances ERK activation, whereas high concentrations lead to the inhibition of ERK activation. Also involved in response to hypoxia by acting as a negative regulator of HIF1A/HIF-1-alpha via its interaction with EGLN3/PHD3. May promote degradation of HIF1A. May act by recruiting signaling complexes to a specific upstream activator. May also be involved in pre-mRNA splicing. Belongs to the WD repeat MORG1 family. Note: This description may include information from UniProtKB.
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Protein type: RNA processing; Spliceosome |
Chromosomal Location of mouse Ortholog: 8|8 C3 |
Cellular Component:
catalytic step 2 spliceosome; cytoplasm; nucleus; spliceosomal complex
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Biological Process:
inflammatory response to wounding; interleukin-6 production; mRNA processing; mRNA splicing, via spliceosome; regulation of I-kappaB kinase/NF-kappaB signaling; response to hypoxia; response to lipopolysaccharide; response to wounding; RNA splicing; RNA splicing, via transesterification reactions; tumor necrosis factor production
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Reference #:
Q9DAJ4
(UniProtKB)
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Alt. Names/Synonyms: 1500041N16Rik; MAPK cascade scaffold protein; MAPK organizer 1; Mitogen-activated protein kinase organizer 1; Mor; Morg1; WD repeat domain containing 83; WD repeat domain-containing protein 83; Wdr83
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Gene Symbols: Wdr83
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Molecular weight:
34,444 Da
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Basal Isoelectric point:
5.56
Predict pI for various phosphorylation states
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