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CD10
Thermolysin-like specificity, but is almost confined on acting on polypeptides of up to 30 amino acids. Biologically important in the destruction of opioid peptides such as Met- and Leu-enkephalins by cleavage of a Gly-Phe bond. Able to cleave angiotensin-1, angiotensin-2 and angiotensin 1-9. Involved in the degradation of atrial natriuretic factor (ANF). Displays UV-inducible elastase activity toward skin preelastic and elastic fibers. Belongs to the peptidase M13 family. Note: This description may include information from UniProtKB.
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| Protein type: EC 3.4.24.11; Membrane protein, integral; Protease |
| Chromosomal Location of human Ortholog: 3q25.2 |
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Cellular Component:
axon; brush border; cell surface; cytoplasm; cytoplasmic vesicle; dendrite; early endosome; membrane; membrane raft; neuron projection terminus; neuronal cell body; plasma membrane; presynapse; secretory granule membrane; synapse; synaptic vesicle; trans-Golgi network
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Molecular Function:
cardiolipin binding; endopeptidase activity; exopeptidase activity; metalloendopeptidase activity; oligopeptidase activity; peptide binding; phosphatidylserine binding; protein binding; protein homodimerization activity; zinc ion binding
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Biological Process:
amyloid-beta clearance; amyloid-beta clearance by cellular catabolic process; amyloid-beta metabolic process; bradykinin catabolic process; cellular response to cytokine stimulus; cellular response to UV-A; cellular response to UV-B; creatinine metabolic process; hormone catabolic process; kidney development; learning or memory; lung development; neuropeptide processing; peptide metabolic process; placenta development; positive regulation of long-term synaptic potentiation; positive regulation of neurogenesis; protein catabolic process; protein processing; proteolysis; replicative senescence; response to estrogen; sensory perception of pain; substance P catabolic process
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Disease: Charcot-marie-tooth Disease, Axonal, Type 2t; Spinocerebellar Ataxia 43
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Reference #:
P08473
(UniProtKB)
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Alt. Names/Synonyms: Atriopeptidase; CALLA; CD10; CMT2T; Common acute lymphocytic leukemia antigen; DKFZp686O16152; Enkephalinase; EPN; membrane metallo-endopeptidase; membrane metallo-endopeptidase (neutral endopeptidase, enkephalinase, CALLA, CD10); membrane metallo-endopeptidase variant 1; membrane metallo-endopeptidase variant 2; membrane metalloendopeptidase; MGC126681; MGC126707; MME; NEP; Neprilysin; neprilysin-390; neprilysin-411; Neutral endopeptidase; Neutral endopeptidase 24.11; SCA43; SFE; Skin fibroblast elastase
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Gene Symbols: MME
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Molecular weight:
85,514 Da
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Basal Isoelectric point:
5.54
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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