NPAS1 May control regulatory pathways relevant to schizophrenia and to psychotic illness. May play a role in late central nervous system development by modulating EPO expression in response to cellular oxygen level. Forms a heterodimer that binds core DNA sequence 5'-TACGTG-3' within the hypoxia response element (HRE) leading to transcriptional repression on its target gene TH. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: DNA-binding
Chromosomal Location of Human Ortholog: 19q13.32
Cellular Component: 
Molecular Function:  DNA binding; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; protein heterodimerization activity
Biological Process:  central nervous system development; maternal behavior; negative regulation of transcription by RNA polymerase II; negative regulation of transcription, DNA-templated; startle response
Reference #:  Q99742 (UniProtKB)
Alt. Names/Synonyms: Basic-helix-loop-helix-PAS protein MOP5; BHLHE11; Class E basic helix-loop-helix protein 11; Member of PAS protein 5; member of PAS superfamily 5; MOP5; neuronal PAS domain protein 1; Neuronal PAS domain-containing protein 1; Neuronal PAS1; NPAS1; PAS domain-containing protein 5; PASD5
Gene Symbols: NPAS1
Molecular weight: 62,702 Da
Basal Isoelectric point: 8.61  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene