NMDAR2B Component of NMDA receptor complexes that function as heterotetrameric, ligand-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Channel activation requires binding of the neurotransmitter glutamate to the epsilon subunit, glycine binding to the zeta subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+). Sensitivity to glutamate and channel kinetics depend on the subunit composition. In concert with DAPK1 at extrasynaptic sites, acts as a central mediator for stroke damage. Its phosphorylation at Ser-1303 by DAPK1 enhances synaptic NMDA receptor channel activity inducing injurious Ca2+ influx through them, resulting in an irreversible neuronal death. Contributes to neural pattern formation in the developing brain. Plays a role in long-term depression (LTD) of hippocampus membrane currents and in synaptic plasticity. Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. NR2B/GRIN2B subfamily. Primarily found in the fronto-parieto-temporal cortex and hippocampus pyramidal cells, lower expression in the basal ganglia. Note: This description may include information from UniProtKB.

Protein type: Channel, calcium; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of human Ortholog: 12p13.1

Cellular Component: cell surface; cytoplasm; cytoskeleton; endoplasmic reticulum membrane; late endosome; lysosome; neuron projection; NMDA selective glutamate receptor complex; plasma membrane; postsynaptic density; postsynaptic density membrane; postsynaptic membrane; synaptic membrane

Molecular Function: amyloid-beta binding; glutamate binding; glutamate-gated calcium ion channel activity; glycine binding; ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential; NMDA glutamate receptor activity; protein binding; transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential; zinc ion binding

Biological Process: brain development; calcium ion transmembrane import into cytosol; calcium-mediated signaling; chemical synaptic transmission; excitatory chemical synaptic transmission; excitatory postsynaptic potential; glutamate receptor signaling pathway; ionotropic glutamate receptor signaling pathway; learning or memory; long-term synaptic potentiation; monoatomic cation transmembrane transport; negative regulation of dendritic spine maintenance; positive regulation of cysteine-type endopeptidase activity; positive regulation of excitatory postsynaptic potential; positive regulation of neuron death; positive regulation of synaptic transmission, glutamatergic; protein heterotetramerization; regulation of monoatomic cation transmembrane transport; regulation of neuronal synaptic plasticity; regulation of presynaptic membrane potential; regulation of synaptic plasticity; response to ethanol; synaptic transmission, glutamatergic

Disease: Epileptic Encephalopathy, Early Infantile, 27; Mental Retardation, Autosomal Dominant 6

Reference #: Q13224 (UniProtKB)

Alt. Names/Synonyms: EIEE27; GluN2B; Glutamate [NMDA] receptor subunit epsilon-2; glutamate ionotropic receptor NMDA type subunit 2B; Glutamate receptor ionotropic, NMDA 2B; glutamate receptor subunit epsilon-2; glutamate receptor, ionotropic, N-methyl D-aspartate 2B; GRIN2B; hNR3; MGC142178; MGC142180; MRD6; N-methyl D-aspartate receptor subtype 2B; N-methyl-D-aspartate receptor subunit 3; NMDAR2B; NMDE2; NR2B; NR3

Gene Symbols: GRIN2B

Molecular weight: 166,367 Da

Basal Isoelectric point: 6.47 Predict pI for various phosphorylation states

CST Pathways: Alzheimer's Disease | Parkinson's Disease

Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology^®

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NMDAR2B

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