PTPN23 Plays a role in sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs) via its interaction with the ESCRT-I complex (endosomal sorting complex required for transport I), and possibly also other ESCRT complexes. May act as a negative regulator of Ras-mediated mitogenic activity. Plays a role in ciliogenesis. Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily. Note: This description may include information from UniProtKB.
Protein type: EC; Motility/polarity/chemotaxis; Protein phosphatase, tyrosine (non-receptor)
Chromosomal Location of human Ortholog: 3p21.31
Cellular Component:  ciliary basal body; cytoplasm; cytosol; early endosome; endosome; nuclear body; nucleoplasm; nucleus
Molecular Function:  protein binding; protein kinase binding; protein tyrosine phosphatase activity
Biological Process:  cellular response to cytokine stimulus; cilium assembly; early endosome to late endosome transport; endocytic recycling; negative regulation of epithelial cell migration; peptidyl-tyrosine dephosphorylation; positive regulation of adherens junction organization; positive regulation of early endosome to late endosome transport; positive regulation of homophilic cell adhesion; positive regulation of Wnt protein secretion; protein transport; ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
Disease: Neurodevelopmental Disorder And Structural Brain Anomalies With Or Without Seizures And Spasticity
Reference #:  Q9H3S7 (UniProtKB)
Alt. Names/Synonyms: DKFZp564F0923; HD-PTP; HDPTP; His domain-containing protein tyrosine phosphatase; His-domain protein tyrosine phosphatase; KIAA1471; NEDBASS; protein tyrosine phosphatase non-receptor type 23; Protein tyrosine phosphatase TD14; protein tyrosine phosphatase, non-receptor type 23; PTN23; PTP-TD14; PTPN23; Tyrosine-protein phosphatase non-receptor type 23
Gene Symbols: PTPN23
Molecular weight: 178,974 Da
Basal Isoelectric point: 6.45  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene