CHST13 Catalyzes the transfer of sulfate to position 4 of the N-acetylgalactosamine (GalNAc) residue of chondroitin. Chondroitin sulfate constitutes the predominant proteoglycan present in cartilage and is distributed on the surfaces of many cells and extracellular matrices. Transfers sulfate to the C4 hydroxyl of beta1,4-linked GalNAc that is substituted with a beta-linked glucuronic acid at the C-3 hydroxyl. No activity toward dermatan. Belongs to the sulfotransferase 2 family. Highly expressed in adult liver. Expressed at lower level in kidney, lymph nodes and fetal kidney. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC; Energy Metabolism - sulfur; Glycan Metabolism - chondroitin sulfate biosynthesis; Membrane protein, integral; Transferase
Chromosomal Location of Human Ortholog: 3q21.3
Cellular Component:  Golgi membrane; integral component of membrane
Molecular Function:  chondroitin 4-sulfotransferase activity; N-acetylgalactosamine 4-O-sulfotransferase activity
Biological Process:  carbohydrate biosynthetic process; chondroitin sulfate biosynthetic process
Reference #:  Q8NET6 (UniProtKB)
Alt. Names/Synonyms: C4ST-3; C4ST3; carbohydrate (chondroitin 4) sulfotransferase 13; Carbohydrate sulfotransferase 13; Chondroitin 4-O-sulfotransferase 3; Chondroitin 4-sulfotransferase 3; CHST13; CHSTD; MGC119278; MGC119279; MGC119281
Gene Symbols: CHST13
Molecular weight: 38,920 Da
Basal Isoelectric point: 10.56  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

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