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E2F2
Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from g1 to s phase. E2F2 binds specifically to RB1 in a cell-cycle dependent manner. Belongs to the E2F/DP family. Highest level of expression is found in placenta, low levels are found in lung. Found as well in many immortalized cell lines derived from tumor samples. Note: This description may include information from UniProtKB.
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| Protein type: DNA-binding |
| Chromosomal Location of human Ortholog: 1p36.12 |
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Cellular Component:
chromatin; nucleoplasm; Rb-E2F complex; RNA polymerase II transcription regulator complex
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Molecular Function:
cis-regulatory region sequence-specific DNA binding; DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; protein binding; protein dimerization activity; RNA polymerase II cis-regulatory region sequence-specific DNA binding; RNA polymerase II transcription regulatory region sequence-specific DNA binding; sequence-specific DNA binding; sequence-specific double-stranded DNA binding
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Biological Process:
intrinsic apoptotic signaling pathway by p53 class mediator; lens fiber cell apoptotic process; negative regulation of DNA-binding transcription factor activity; negative regulation of sprouting angiogenesis; positive regulation of transcription by RNA polymerase II; regulation of cell cycle; regulation of transcription by RNA polymerase II; regulation of transcription involved in G1/S transition of mitotic cell cycle; transcription initiation at RNA polymerase II promoter
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Reference #:
Q14209
(UniProtKB)
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Alt. Names/Synonyms: E2F transcription factor 2; E2F-2; E2F2; Transcription factor E2F2
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Gene Symbols: E2F2
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Molecular weight:
47,506 Da
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Basal Isoelectric point:
4.75
Predict pI for various phosphorylation states
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CST Pathways:
ErbB/HER Signaling
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G1/S Checkpoint
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