EIF5A mRNA-binding protein involved in translation elongation. Has an important function at the level of mRNA turnover, probably acting downstream of decapping. Involved in actin dynamics and cell cycle progression, mRNA decay and probably in a pathway involved in stress response and maintenance of cell wall integrity. With syntenin SDCBP, functions as a regulator of p53/TP53 and p53/TP53-dependent apoptosis. Regulates also TNF-alpha-mediated apoptosis. Mediates effects of polyamines on neuronal process extension and survival. May play an important role in brain development and function, and in skeletal muscle stem cell differentiation. Also described as a cellular cofactor of human T-cell leukemia virus type I (HTLV-1) Rex protein and of human immunodeficiency virus type 1 (HIV-1) Rev protein, essential for mRNA export of retroviral transcripts. Belongs to the eIF-5A family. Expressed in umbilical vein endothelial cells and several cancer cell lines (at protein level). 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Translation; Translation initiation
Chromosomal Location of mouse Ortholog: 11|11 B3
Cellular Component:  annulate lamellae; cytoplasm; dendrite; endoplasmic reticulum; membrane; neuronal cell body; nuclear pore; nucleus; synapse
Molecular Function:  protein N-terminus binding; ribosome binding; RNA binding; translation elongation factor activity; U6 snRNA binding
Biological Process:  apoptotic process; mRNA export from nucleus; mRNA transport; negative regulation of apoptotic process; positive regulation of apoptotic process; positive regulation of cardiac muscle cell apoptotic process; positive regulation of cell proliferation; positive regulation of cytosolic calcium ion concentration; positive regulation of muscle cell differentiation; positive regulation of reactive oxygen species metabolic process; positive regulation of translational elongation; positive regulation of translational termination; protein export from nucleus; protein transport; translation; translational elongation; translational frameshifting
Reference #:  P63242 (UniProtKB)
Alt. Names/Synonyms: AA410058; D19Wsu54; D19Wsu54e; eIF-4D; eIF-5A; eIF-5A-1; eIF-5A1; Eif4d; Eif5a; Eif5a1; eukaryotic initiation factor 5A; Eukaryotic initiation factor 5A isoform 1; eukaryotic translation initiation factor 5A; Eukaryotic translation initiation factor 5A-1; Eukaryotic translation initiation factor 5A1; IF5A1; MGC6725; OTTMUSP00000006258; OTTMUSP00000006259; OTTMUSP00000006260; OTTMUSP00000006261; OTTMUSP00000006262; OTTMUSP00000006263; OTTMUSP00000006264; OTTMUSP00000006265; OTTMUSP00000016809; OTTMUSP00000016810
Gene Symbols: Eif5a
Molecular weight: 16,832 Da
Basal Isoelectric point: 5.07  Predict pI for various phosphorylation states
CST Pathways:  Translation: eIF2  |  Translational Control
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene