DNAJC5 Acts as a general chaperone in regulated exocytosis. Acts as a co-chaperone for the SNARE protein SNAP-25. Involved in the calcium-mediated control of a late stage of exocytosis. May have an important role in presynaptic function. May be involved in calcium-dependent neurotransmitter release at nerve endings. Expressed in pancreas, kidney, skeletal muscle, liver, lung, placenta, brain and heart. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Vesicle
Chromosomal Location of human Ortholog: 20q13.33
Cellular Component:  azurophil granule membrane; chromaffin granule membrane; clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane; cytosol; Golgi apparatus; intracellular membrane-bounded organelle; melanosome; membrane; neuromuscular junction; plasma membrane; presynapse; specific granule membrane; synaptic vesicle membrane
Molecular Function:  ATP-dependent protein binding; protein binding
Biological Process:  chaperone-mediated protein folding; exocytosis; negative regulation of neuron apoptotic process; neuron apoptotic process; regulated exocytosis; regulation of synaptic vesicle cycle; synaptic vesicle exocytosis
Disease: Ceroid Lipofuscinosis, Neuronal, 4b, Autosomal Dominant
Reference #:  Q9H3Z4 (UniProtKB)
Alt. Names/Synonyms: Ceroid-lipofuscinosis neuronal protein 4; CLN4; CLN4B; CSP; Cysteine string protein; cysteine string protein alpha; DKFZp434N1429; DKFZp761N1221; DnaJ (Hsp40) homolog, subfamily C, member 5; DnaJ heat shock protein family (Hsp40) member C5; DnaJ homolog subfamily C member 5; DNAJC5; DNAJC5A; DNJC5; FLJ00118; FLJ13070; mir-941-2; mir-941-3; mir-941-4; mir-941-5; NCL
Gene Symbols: DNAJC5
Molecular weight: 22,149 Da
Basal Isoelectric point: 4.93  Predict pI for various phosphorylation states
Select Structure to View Below

DNAJC5

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein