DNAJC5
Acts as a general chaperone in regulated exocytosis. Acts as a co-chaperone for the SNARE protein SNAP-25. Involved in the calcium-mediated control of a late stage of exocytosis. May have an important role in presynaptic function. May be involved in calcium-dependent neurotransmitter release at nerve endings. Expressed in pancreas, kidney, skeletal muscle, liver, lung, placenta, brain and heart. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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Protein type: Vesicle |
Chromosomal Location of human Ortholog: 20q13.33 |
Cellular Component:
azurophil granule membrane; chromaffin granule membrane; clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane; cytosol; Golgi apparatus; intracellular membrane-bounded organelle; melanosome; membrane; neuromuscular junction; plasma membrane; presynapse; specific granule membrane; synaptic vesicle membrane
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Molecular Function:
ATP-dependent protein binding; protein binding
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Biological Process:
chaperone-mediated protein folding; exocytosis; negative regulation of neuron apoptotic process; neuron apoptotic process; regulated exocytosis; regulation of synaptic vesicle cycle; synaptic vesicle exocytosis
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Disease: Ceroid Lipofuscinosis, Neuronal, 4b, Autosomal Dominant
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Reference #:
Q9H3Z4
(UniProtKB)
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Alt. Names/Synonyms: Ceroid-lipofuscinosis neuronal protein 4; CLN4; CLN4B; CSP; Cysteine string protein; cysteine string protein alpha; DKFZp434N1429; DKFZp761N1221; DnaJ (Hsp40) homolog, subfamily C, member 5; DnaJ heat shock protein family (Hsp40) member C5; DnaJ homolog subfamily C member 5; DNAJC5; DNAJC5A; DNJC5; FLJ00118; FLJ13070; mir-941-2; mir-941-3; mir-941-4; mir-941-5; NCL
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Gene Symbols: DNAJC5
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Molecular weight:
22,149 Da
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Basal Isoelectric point:
4.93
Predict pI for various phosphorylation states
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