ACC1 a subunit of acetyl-CoA carboxylase (ACC), a multifunctional enzyme system. Catalyzes the rate-limiting reaction in the biogenesis of long-chain fatty acids. Carries out three functions: biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase. Expressed in brain, placental, skeletal muscle, renal, pancreatic and adipose tissues; expressed at low level in pulmonary tissue; not detected in the liver. 4 human isoforms generated by alternative promoter usage have been reported. Note: This description may include information from UniProtKB.
Protein type: Carbohydrate Metabolism - propanoate; Carbohydrate Metabolism - pyruvate; EC; EC; Ligase; Lipid Metabolism - fatty acid biosynthesis
Chromosomal Location of rat Ortholog: 10q26
Cellular Component:  actin cytoskeleton; cytosol; fibrillar center; mitochondrion
Molecular Function:  acetyl-CoA carboxylase activity; ATP binding; biotin binding; identical protein binding; kinase binding; metal ion binding
Biological Process:  acetyl-CoA metabolic process; cellular response to prostaglandin E stimulus; fatty acid biosynthetic process; lipid homeostasis; lipid metabolic process; malonyl-CoA biosynthetic process; protein homotetramerization; protein metabolic process; response to nutrient levels; response to organic cyclic compound; response to xenobiotic stimulus; tissue homeostasis
Reference #:  P11497 (UniProtKB)
Alt. Names/Synonyms: Acac; Acaca; ACC-alpha; ACC1; Acetyl-CoA carboxylase 1; acetyl-coenzyme A carboxylase alpha; Biotin carboxylase
Gene Symbols: Acaca
Molecular weight: 265,194 Da
Basal Isoelectric point: 5.97  Predict pI for various phosphorylation states
CST Pathways:  AMPK Signaling  |  Warburg Effect
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene