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ACC1
a subunit of acetyl-CoA carboxylase (ACC), a multifunctional enzyme system. Catalyzes the rate-limiting reaction in the biogenesis of long-chain fatty acids. Carries out three functions: biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase. Expressed in brain, placental, skeletal muscle, renal, pancreatic and adipose tissues; expressed at low level in pulmonary tissue; not detected in the liver. 4 human isoforms generated by alternative promoter usage have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Carbohydrate Metabolism - propanoate; Carbohydrate Metabolism - pyruvate; EC 6.3.4.14; EC 6.4.1.2; Ligase; Lipid Metabolism - fatty acid biosynthesis |
| Chromosomal Location of rat Ortholog: 10q26 |
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Cellular Component:
actin cytoskeleton; cytosol; fibrillar center; mitochondrion
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Molecular Function:
acetyl-CoA carboxylase activity; ATP binding; biotin binding; identical protein binding; kinase binding; metal ion binding
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Biological Process:
acetyl-CoA metabolic process; cellular response to prostaglandin E stimulus; fatty acid biosynthetic process; lipid biosynthetic process; lipid homeostasis; lipid metabolic process; malonyl-CoA biosynthetic process; protein homotetramerization; protein metabolic process; response to nutrient levels; response to organic cyclic compound; response to xenobiotic stimulus; tissue homeostasis
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Reference #:
P11497
(UniProtKB)
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Alt. Names/Synonyms: Acac; Acaca; ACC-alpha; ACC1; Acetyl-CoA carboxylase 1; acetyl-coenzyme A carboxylase alpha; Biotin carboxylase
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Gene Symbols: Acaca
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Molecular weight:
265,194 Da
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Basal Isoelectric point:
5.97
Predict pI for various phosphorylation states
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CST Pathways:
AMPK Signaling
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Warburg Effect
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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