SHP-1 Modulates signaling by tyrosine phosphorylated cell surface receptors such as KIT and the EGF receptor/EGFR. The SH2 regions may interact with other cellular components to modulate its own phosphatase activity against interacting substrates. Together with MTUS1, induces UBE2V2 expression upon angiotensin II stimulation. Plays a key role in hematopoiesis. Belongs to the protein-tyrosine phosphatase family. Non-receptor class 2 subfamily. Isoform 1 is expressed in hematopoietic cells. Isoform 2 is expressed in non-hematopoietic cells. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC; Motility/polarity/chemotaxis; Protein phosphatase, tyrosine (non-receptor)
Chromosomal Location of Human Ortholog: 12p13.31
Cellular Component:  alpha-beta T cell receptor complex; cell-cell junction; cytoplasm; cytosol; extracellular region; membrane; nucleolus; nucleoplasm; nucleus; protein-containing complex; specific granule lumen; tertiary granule lumen
Molecular Function:  cell adhesion molecule binding; phosphorylation-dependent protein binding; phosphotyrosine residue binding; protein binding; protein kinase binding; protein tyrosine phosphatase activity; SH2 domain binding; SH3 domain binding; transmembrane receptor protein tyrosine phosphatase activity
Biological Process:  abortive mitotic cell cycle; apoptotic process; B cell receptor signaling pathway; cell differentiation; cell proliferation; cellular response to cytokine stimulus; cytokine-mediated signaling pathway; G protein-coupled receptor signaling pathway; hematopoietic progenitor cell differentiation; intracellular signal transduction; leukocyte migration; megakaryocyte development; natural killer cell mediated cytotoxicity; negative regulation of cell proliferation; negative regulation of humoral immune response mediated by circulating immunoglobulin; negative regulation of interleukin-6 production; negative regulation of MAP kinase activity; negative regulation of peptidyl-tyrosine phosphorylation; negative regulation of T cell proliferation; negative regulation of T cell receptor signaling pathway; negative regulation of tumor necrosis factor production; neutrophil degranulation; peptidyl-tyrosine dephosphorylation; peptidyl-tyrosine phosphorylation; platelet activation; platelet aggregation; platelet formation; positive regulation of cell adhesion mediated by integrin; positive regulation of cell proliferation; positive regulation of phosphatidylinositol 3-kinase signaling; protein dephosphorylation; regulation of B cell differentiation; regulation of ERK1 and ERK2 cascade; regulation of G1/S transition of mitotic cell cycle; regulation of release of sequestered calcium ion into cytosol; regulation of type I interferon-mediated signaling pathway; T cell costimulation
Reference #:  P29350 (UniProtKB)
Alt. Names/Synonyms: HCP; HCPH; hematopoietic cell phosphatase; Hematopoietic cell protein-tyrosine phosphatase; HPTP1C; protein tyrosine phosphatase, non-receptor type 6; Protein-tyrosine phosphatase 1C; Protein-tyrosine phosphatase SHP-1; PTN6; PTP-1C; PTP1C; PTPN6; SH-PTP1; SHP-1; SHP-1L; SHP1; Tyrosine-protein phosphatase non-receptor type 6
Gene Symbols: PTPN6
Molecular weight: 67,561 Da
Basal Isoelectric point: 7.65  Predict pI for various phosphorylation states
CST Pathways:  B Cell Receptor Signaling  |  IL6 Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB  |  Ensembl Protein