HePTP a non-receptor protein-tyrosine phosphatase. Preferentially expressed in a variety of hematopoietic cells, and is an early response gene in lymphokine stimulated cells. Its noncatalytic N-terminus can interact with MAP kinases and suppress the MAP kinase activities. Shown to be involved in the regulation of T cell antigen receptor (TCR) signaling, which was thought to function through dephosphorylating the molecules related to MAP kinase pathway. Three alternatively spliced transcript variants of this gene, which encode two distinct isoforms, are reported. May play a role in the regulation of lymphocyte development. Note: This description may include information from UniProtKB.
Protein type: EC 3.1.3.48; Motility/polarity/chemotaxis; Protein phosphatase, tyrosine (non-receptor)
Chromosomal Location of Human Ortholog: 1q32.1
Cellular Component:  cytoplasm; cytoplasmic side of plasma membrane; cytoskeleton; cytosol; nucleoplasm
Molecular Function:  protein binding; protein tyrosine phosphatase activity
Biological Process:  cellular response to cytokine stimulus; peptidyl-tyrosine dephosphorylation; protein dephosphorylation
Reference #:  P35236 (UniProtKB)
Alt. Names/Synonyms: BPTP-4; dual specificity phosphatase 1; Hematopoietic protein-tyrosine phosphatase; HEPTP; LC-PTP; LPTP; protein tyrosine phosphatase, non-receptor type 7; Protein-tyrosine phosphatase LC-PTP; protein-tyrosine phosphatase, nonreceptor-type, stress induced; PTN7; PTPN7; PTPNI; Tyrosine-protein phosphatase non-receptor type 7
Gene Symbols: PTPN7
Molecular weight: 40,529 Da
Basal Isoelectric point: 6.33  Predict pI for various phosphorylation states
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HePTP

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene