nAChRA4 After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane permeable to sodium ions. Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Alpha-4/CHRNA4 sub-subfamily. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass; Receptor, misc.
Chromosomal Location of Human Ortholog: 20q13.33
Cellular Component:  acetylcholine-gated channel complex; cell junction; dendrite; dopaminergic synapse; external side of plasma membrane; integral component of membrane; integral component of presynaptic membrane; membrane; neuronal cell body; plasma membrane; postsynaptic membrane
Molecular Function:  acetylcholine binding; acetylcholine receptor activity; acetylcholine-gated cation-selective channel activity; ligand-gated ion channel activity; protein binding
Biological Process:  acetylcholine receptor signaling pathway; action potential; B cell activation; behavioral response to nicotine; calcium ion transport; chemical synaptic transmission; cognition; DNA repair; excitatory postsynaptic potential; exploration behavior; inhibitory postsynaptic potential; ion transport; locomotory behavior; membrane depolarization; nervous system process; regulation of dopamine secretion; regulation of membrane potential; regulation of synaptic vesicle exocytosis; respiratory gaseous exchange; response to hypoxia; response to nicotine; response to oxidative stress; sensory perception of pain; signal transduction; synaptic transmission, cholinergic
Disease: Epilepsy, Nocturnal Frontal Lobe, 1; Tobacco Addiction, Susceptibility To
Reference #:  P43681 (UniProtKB)
Alt. Names/Synonyms: ACHA4; BFNC; cholinergic receptor nicotinic alpha 4 subunit; cholinergic receptor, nicotinic alpha 4; cholinergic receptor, nicotinic, alpha 4; cholinergic receptor, nicotinic, alpha 4 (neuronal); cholinergic receptor, nicotinic, alpha polypeptide 4; CHRNA4; EBN; EBN1; FLJ95812; NACHR; NACHRA4; NACRA4; Neuronal acetylcholine receptor subunit alpha-4; neuronal nicotinic acetylcholine receptor alpha-4 subunit
Gene Symbols: CHRNA4
Molecular weight: 69,957 Da
Basal Isoelectric point: 6.81  Predict pI for various phosphorylation states
CST Pathways:  Alzheimer's Disease
Select Structure to View Below


Protein Structure Not Found.

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