ST14 Degrades extracellular matrix. Proposed to play a role in breast cancer invasion and metastasis. Exhibits trypsin-like activity as defined by cleavage of synthetic substrates with Arg or Lys as the P1 site. Involved in the terminal differentiation of keratinocytes through prostasin (PRSS8) activation and filaggrin (FLG) processing. Belongs to the peptidase S1 family. Note: This description may include information from UniProtKB.
Protein type: EC; Membrane protein, integral; Protease
Chromosomal Location of human Ortholog: 11q24.3
Cellular Component:  basolateral plasma membrane; external side of plasma membrane; extracellular space; extrinsic component of plasma membrane; plasma membrane
Molecular Function:  serine-type endopeptidase activity; serine-type peptidase activity
Biological Process:  epithelial cell morphogenesis involved in placental branching; keratinocyte differentiation; neural tube closure; protein catabolic process; proteolysis
Disease: Ichthyosis, Congenital, Autosomal Recessive 11
Reference #:  Q9Y5Y6 (UniProtKB)
Alt. Names/Synonyms: ARCI11; HAI; Matriptase; Membrane-type serine protease 1; MT-SP1; MTSP1; Prostamin; PRSS14; Serine protease 14; Serine protease TADG-15; SNC19; ST14; ST14 transmembrane serine protease matriptase; suppression of tumorigenicity 14 (colon carcinoma); suppression of tumorigenicity 14 (colon carcinoma, matriptase, epithin); Suppressor of tumorigenicity 14 protein; TADG15; TMPRSS14; tumor associated differentially expressed gene 15 protein; Tumor-associated differentially-expressed gene 15 protein
Gene Symbols: ST14
Molecular weight: 94,770 Da
Basal Isoelectric point: 6.11  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene