TMEM24 Lipid-binding protein that transports phosphatidylinositol, the precursor of phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2), from its site of synthesis in the endoplasmic reticulum to the cell membrane. It thereby maintains the pool of cell membrane phosphoinositides, which are degraded during phospholipase C (PLC) signaling. Plays a key role in the coordination of Ca(2+) and phosphoinositide signaling: localizes to sites of contact between the endoplasmic reticulum and the cell membrane, where it tethers the two bilayers. In response to elevation of cytosolic Ca(2+), it is phosphorylated at its C-terminus and dissociates from the cell membrane, abolishing phosphatidylinositol transport to the cell membrane. Positively regulates insulin secretion in response to glucose: phosphatidylinositol transfer to the cell membrane allows replenishment of PI(4,5)P2 pools and calcium channel opening, priming a new population of insulin granules. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral
Chromosomal Location of Human Ortholog: 9|9 A5.2
Cellular Component:  cortical endoplasmic reticulum; endoplasmic reticulum; integral component of membrane; membrane; plasma membrane
Molecular Function:  insulin binding; lipid binding; phosphatidylinositol binding; phosphatidylinositol transporter activity; phospholipid transporter activity
Biological Process:  lipid transport; positive regulation of insulin secretion involved in cellular response to glucose stimulus
Reference #:  Q80X80 (UniProtKB)
Alt. Names/Synonyms: 1300006O23Rik; C2 calcium-dependent domain containing 2-like; C2 domain-containing protein 2-like; C2C2L; C2cd2l; Phospholipid transfer protein C2CD2L; Tmem24; Transmembrane protein 24
Gene Symbols: C2cd2l
Molecular weight: 76,329 Da
Basal Isoelectric point: 6.8  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene