TMEM24
Lipid-binding protein that transports phosphatidylinositol, the precursor of phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2), from its site of synthesis in the endoplasmic reticulum to the cell membrane. It thereby maintains the pool of cell membrane phosphoinositides, which are degraded during phospholipase C (PLC) signaling. Plays a key role in the coordination of Ca(2+) and phosphoinositide signaling: localizes to sites of contact between the endoplasmic reticulum and the cell membrane, where it tethers the two bilayers. In response to elevation of cytosolic Ca(2+), it is phosphorylated at its C-terminus and dissociates from the cell membrane, abolishing phosphatidylinositol transport to the cell membrane. Positively regulates insulin secretion in response to glucose: phosphatidylinositol transfer to the cell membrane allows replenishment of PI(4,5)P2 pools and calcium channel opening, priming a new population of insulin granules. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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Protein type: Membrane protein, integral |
Chromosomal Location of mouse Ortholog: 9|9 A5.2 |
Cellular Component:
cortical endoplasmic reticulum; cytoplasmic side of apical plasma membrane; endoplasmic reticulum; endoplasmic reticulum-plasma membrane contact site; membrane; plasma membrane
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Molecular Function:
insulin binding; lipid binding; phosphatidylinositol binding; phosphatidylinositol transfer activity
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Biological Process:
lipid transport; positive regulation of insulin secretion involved in cellular response to glucose stimulus
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Reference #:
Q80X80
(UniProtKB)
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Alt. Names/Synonyms: 1300006O23Rik; C2 calcium-dependent domain containing 2-like; C2 domain-containing protein 2-like; C2C2L; C2cd2l; Phospholipid transfer protein C2CD2L; Tmem24; Transmembrane protein 24
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Gene Symbols: C2cd2l
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Molecular weight:
76,329 Da
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Basal Isoelectric point:
6.8
Predict pI for various phosphorylation states
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