EIF5 Catalyzes the hydrolysis of GTP bound to the 40S ribosomal initiation complex (40S.mRNA.Met-tRNA[F].eIF-2.GTP) with the subsequent joining of a 60S ribosomal subunit resulting in the release of eIF-2 and the guanine nucleotide. The subsequent joining of a 60S ribosomal subunit results in the formation of a functional 80S initiation complex (80S.mRNA.Met-tRNA[F]). Belongs to the eIF-2-beta/eIF-5 family. Note: This description may include information from UniProtKB.
Protein type: Translation; Translation initiation
Chromosomal Location of Human Ortholog: 14q32.32
Cellular Component:  cytoplasm; cytosol; plasma membrane
Molecular Function:  eukaryotic initiation factor eIF2 binding; GTP binding; GTPase activity; protein binding; translation factor activity, RNA binding; translation initiation factor activity
Biological Process:  activation of GTPase activity; formation of translation preinitiation complex; regulation of translational initiation; translational initiation
Reference #:  P55010 (UniProtKB)
Alt. Names/Synonyms: eIF-5; EIF-5A; EIF5; Eukaryotic translation initiation factor 5; IF5
Gene Symbols: EIF5
Molecular weight: 49,223 Da
Basal Isoelectric point: 5.41  Predict pI for various phosphorylation states
CST Pathways:  Translation: eIF2  |  Translational Control
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB  |  Ensembl Protein