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EIF5
Catalyzes the hydrolysis of GTP bound to the 40S ribosomal initiation complex (40S.mRNA.Met-tRNA[F].eIF-2.GTP) with the subsequent joining of a 60S ribosomal subunit resulting in the release of eIF-2 and the guanine nucleotide. The subsequent joining of a 60S ribosomal subunit results in the formation of a functional 80S initiation complex (80S.mRNA.Met-tRNA[F]). Belongs to the eIF-2-beta/eIF-5 family. Note: This description may include information from UniProtKB.
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| Protein type: Translation; Translation initiation |
| Chromosomal Location of Human Ortholog: 14q32.32 |
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Cellular Component:
cytoplasm; cytosol; plasma membrane
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Molecular Function:
eukaryotic initiation factor eIF2 binding; GTP binding; GTPase activity; protein binding; translation factor activity, RNA binding; translation initiation factor activity
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Biological Process:
activation of GTPase activity; formation of translation preinitiation complex; regulation of translational initiation; translational initiation
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Reference #:
P55010
(UniProtKB)
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Alt. Names/Synonyms: eIF-5; EIF-5A; EIF5; Eukaryotic translation initiation factor 5; IF5
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Gene Symbols: EIF5
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Molecular weight:
49,223 Da
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Basal Isoelectric point:
5.41
Predict pI for various phosphorylation states
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CST Pathways:
Translation: eIF2
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Translational Control
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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