RAD23A Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Binds to 'Lys-48'-linked polyubiquitin chains in a length-dependent manner and with a lower affinity to 'Lys-63'-linked polyubiquitin chains. Proposed to be capable to bind simultaneously to the 26S proteasome and to polyubiquitinated substrates and to deliver ubiquitinated proteins to the proteasome. Involved in nucleotide excision repair and is thought to be functional equivalent for RAD23B in global genome nucleotide excision repair (GG-NER) by association with XPC. In vitro, the XPC:RAD23A dimer has NER activity. Can stabilize XPC. (Microbial infection) Involved in Vpr-dependent replication of HIV-1 in non-proliferating cells and primary macrophages. Required for the association of HIV-1 Vpr with the host proteasome. Belongs to the RAD23 family. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: DNA repair, damage; DNA-binding
Chromosomal Location of Human Ortholog: 8|8 C2
Cellular Component:  cytoplasm; cytosol; intracellular membrane-bounded organelle; microtubule organizing center; nucleoplasm; nucleus; proteasome complex; protein-containing complex
Molecular Function:  damaged DNA binding; kinase binding; polyubiquitin modification-dependent protein binding; proteasome binding; ubiquitin binding; ubiquitin-specific protease binding
Biological Process:  cellular response to DNA damage stimulus; DNA repair; nucleotide-excision repair; positive regulation of cell cycle; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; positive regulation of viral genome replication; proteasome-mediated ubiquitin-dependent protein catabolic process; protein destabilization; regulation of proteasomal ubiquitin-dependent protein catabolic process
Reference #:  P54726 (UniProtKB)
Alt. Names/Synonyms: 2310040P19Rik; AL024030; HR23A; Mhr23a; OTTMUSP00000025196; Rad23a; RAD23a homolog (S. cerevisiae); RD23A; UV excision repair protein RAD23 homolog A
Gene Symbols: Rad23a
Molecular weight: 39,706 Da
Basal Isoelectric point: 4.56  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene