PPIL1 Involved in pre-mRNA splicing as component of the spliceosome. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Belongs to the cyclophilin-type PPIase family. PPIL1 subfamily. Ubiquitous, with the most abundant expression in heart and skeletal muscle. Note: This description may include information from UniProtKB.
Protein type: Cyclophilin; EC; Isomerase; Spliceosome
Chromosomal Location of human Ortholog: 6p21.2
Cellular Component:  catalytic step 2 spliceosome; nucleoplasm; nucleus; U2-type catalytic step 2 spliceosome
Molecular Function:  cyclosporin A binding; disordered domain specific binding; peptidyl-prolyl cis-trans isomerase activity; protein binding
Biological Process:  embryonic brain development; mRNA splicing, via spliceosome; protein folding; protein peptidyl-prolyl isomerization
Disease: Pontocerebellar Hypoplasia, Type 14
Reference #:  Q9Y3C6 (UniProtKB)
Alt. Names/Synonyms: CGI-124; cyclophilin like 1; cyclophilin-related gene 1; CYPL1; hCyPX; MGC678; peptidyl-prolyl cis-trans isomerase; Peptidyl-prolyl cis-trans isomerase-like 1; peptidylprolyl isomerase (cyclophilin)-like 1; peptidylprolyl isomerase like 1; PPIase; PPIL1; Rotamase PPIL1
Gene Symbols: PPIL1
Molecular weight: 18,237 Da
Basal Isoelectric point: 7.78  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene