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PPIL1
Involved in pre-mRNA splicing as component of the spliceosome. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Belongs to the cyclophilin-type PPIase family. PPIL1 subfamily. Ubiquitous, with the most abundant expression in heart and skeletal muscle. Note: This description may include information from UniProtKB.
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| Protein type: Cyclophilin; EC 5.2.1.8; Isomerase; Spliceosome |
| Chromosomal Location of human Ortholog: 6p21.2 |
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Cellular Component:
catalytic step 2 spliceosome; nucleoplasm; nucleus; U2-type catalytic step 2 spliceosome
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Molecular Function:
cyclosporin A binding; disordered domain specific binding; peptidyl-prolyl cis-trans isomerase activity; protein binding
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Biological Process:
embryonic brain development; mRNA splicing, via spliceosome; protein folding; protein peptidyl-prolyl isomerization
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Disease: Pontocerebellar Hypoplasia, Type 14
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Reference #:
Q9Y3C6
(UniProtKB)
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Alt. Names/Synonyms: CGI-124; cyclophilin like 1; cyclophilin-related gene 1; CYPL1; hCyPX; MGC678; peptidyl-prolyl cis-trans isomerase; Peptidyl-prolyl cis-trans isomerase-like 1; peptidylprolyl isomerase (cyclophilin)-like 1; peptidylprolyl isomerase like 1; PPIase; PPIL1; Rotamase PPIL1
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Gene Symbols: PPIL1
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Molecular weight:
18,237 Da
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Basal Isoelectric point:
7.78
Predict pI for various phosphorylation states
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