PLCG2 The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. It is a crucial enzyme in transmembrane signaling. Note: This description may include information from UniProtKB.
Protein type: Carbohydrate Metabolism - inositol phosphate; EC; Motility/polarity/chemotaxis; Phospholipase
Chromosomal Location of Human Ortholog: 16q23.3
Cellular Component:  cytosol; plasma membrane
Molecular Function:  phosphatidylinositol phospholipase C activity; phospholipase C activity; phosphotyrosine residue binding; protein binding
Biological Process:  activation of store-operated calcium channel activity; B cell differentiation; B cell receptor signaling pathway; calcium-mediated signaling; Fc-epsilon receptor signaling pathway; Fc-gamma receptor signaling pathway involved in phagocytosis; follicular B cell differentiation; inositol phosphate metabolic process; negative regulation of programmed cell death; phosphatidylinositol biosynthetic process; phospholipid catabolic process; platelet activation; positive regulation of receptor internalization; positive regulation of type I interferon production; regulation of gene expression; release of sequestered calcium ion into cytosol; response to lipopolysaccharide; stimulatory C-type lectin receptor signaling pathway; T cell receptor signaling pathway; Wnt signaling pathway
Disease: Autoinflammation, Antibody Deficiency, And Immune Dysregulation, Plcg2-associated; Familial Cold Autoinflammatory Syndrome 3
Reference #:  P16885 (UniProtKB)
Alt. Names/Synonyms: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2; 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-2; APLAID; FCAS3; Phosphoinositide phospholipase C-gamma-2; phospholipase C gamma 2; phospholipase C, gamma 2 (phosphatidylinositol-specific); phospholipase C, gamma 2 (phosphatidylyinositol-specific); Phospholipase C-gamma-2; Phospholipase C-IV; PLC-gamma-2; PLC-IV; PLCG2
Gene Symbols: PLCG2
Molecular weight: 147,870 Da
Basal Isoelectric point: 6.21  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  Angiogenesis  |  B Cell Receptor Signaling  |  ErbB/HER Signaling  |  Growth And Differentiation Control by MAPKs
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene