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TRIT1
Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 of both cytosolic and mitochondrial tRNAs, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A). Belongs to the IPP transferase family. 6 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: EC 2.5.1.75; Transferase |
| Chromosomal Location of human Ortholog: 1p34.2 |
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Cellular Component:
mitochondrial matrix; mitochondrion
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Molecular Function:
ATP binding; nucleic acid binding; tRNA dimethylallyltransferase activity; zinc ion binding
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Biological Process:
mitochondrial tRNA modification; tRNA modification
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Disease: Combined Oxidative Phosphorylation Deficiency 35
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Reference #:
Q9H3H1
(UniProtKB)
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Alt. Names/Synonyms: COXPD35; FLJ20061; GRO1; hGRO1; IPP transferase; IPPT; IPT; IPTase; Isopentenyl-diphosphate:tRNA isopentenyltransferase; MGC149242; MGC149243; MOD5; TRIT1; tRNA dimethylallyltransferase; tRNA dimethylallyltransferase, mitochondrial; tRNA isopentenylpyrophosphate transferase; tRNA isopentenyltransferase; tRNA isopentenyltransferase 1
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Gene Symbols: TRIT1
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Molecular weight:
52,725 Da
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Basal Isoelectric point:
8.35
Predict pI for various phosphorylation states
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