HIST3H2A Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Belongs to the histone H2A family. Note: This description may include information from UniProtKB.
Protein type: DNA-binding
Chromosomal Location of Human Ortholog: 1q42.13
Cellular Component:  nuclear nucleosome
Molecular Function:  DNA binding; protein binding; protein heterodimerization activity
Biological Process:  nucleosome disassembly; UV-damage excision repair
Reference #:  Q7L7L0 (UniProtKB)
Alt. Names/Synonyms: H2A3; HIST3H2A; histone 3, H2a; histone cluster 3, H2a; Histone H2A type 3; MGC3165
Gene Symbols: HIST3H2A
Molecular weight: 14,121 Da
Basal Isoelectric point: 11.05  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene