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SELT
Selenoprotein with thioredoxin reductase-like oxidoreductase activity. Protects dopaminergic neurons against oxidative stress ans cell death. Involved in ADCYAP1/PACAP-induced calcium mobilization and neuroendocrine secretion. Plays a role in fibroblast anchorage and redox regulation. In gastric smooth muscle, modulates the contraction processes through the regulation of calcium release and MYLK activation. In pancreatic islets, involved in the control of glucose homeostasis, contributes to prolonged ADCYAP1/PACAP-induced insulin secretion. Belongs to the SelWTH family. Selenoprotein T subfamily. Ubiquitous. Highly expressed in the endocrine pancreas. Note: This description may include information from UniProtKB.
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| Protein type: Secreted; Secreted, signal peptide |
| Chromosomal Location of Human Ortholog: 3|3 D |
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Cellular Component:
endoplasmic reticulum; endoplasmic reticulum membrane; integral component of membrane; membrane
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Molecular Function:
oxidoreductase activity; thioredoxin-disulfide reductase activity
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Biological Process:
cell redox homeostasis; cellular oxidant detoxification; glucose homeostasis; insulin secretion involved in cellular response to glucose stimulus; oxidation-reduction process; pancreas development; positive regulation of cytosolic calcium ion concentration; positive regulation of growth hormone secretion; response to glucose
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Reference #:
P62342
(UniProtKB)
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Alt. Names/Synonyms: 2810407C02Rik; 5730408P04Rik; OTTMUSP00000023471; RIKEN cDNA 2810407C02 gene; Selenoprotein T; Selenot; SelT; thioredoxin reductase-like enzyme; Thioredoxin reductase-like selenoprotein T
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Gene Symbols: Selenot
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Molecular weight:
22,292 Da
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Basal Isoelectric point:
8.79
Predict pI for various phosphorylation states
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