RTN4RL2 Cell surface receptor that plays a functionally redundant role in the inhibition of neurite outgrowth mediated by MAG. Plays a functionally redundant role in postnatal brain development. Contributes to normal axon migration across the brain midline and normal formation of the corpus callosum. Does not seem to play a significant role in regulating axon regeneration in the adult central nervous system. Protects motoneurons against apoptosis; protection against apoptosis is probably mediated by MAG. Like other family members, plays a role in restricting the number dendritic spines and the number of synapses that are formed during brain development. Signaling mediates activation of Rho and downstream reorganization of the actin cytoskeleton. Belongs to the Nogo receptor family. Highly expressed in brain and liver. Expressed at lower levels in kidney, mammary gland, placenta, skeletal muscle, spleen and thyroid. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Cell development/differentiation; Membrane protein, GPI anchor; Receptor, misc.
Chromosomal Location of Human Ortholog: 11q12.1
Cellular Component:  anchored component of plasma membrane; axon; cell surface; dendrite; external side of plasma membrane; extracellular region; membrane raft; neuron projection; perikaryon; plasma membrane
Molecular Function:  signaling receptor activity
Biological Process:  axon regeneration; cell surface receptor signaling pathway; corpus callosum development; negative regulation of neuron projection development
Reference #:  Q86UN3 (UniProtKB)
Alt. Names/Synonyms: NgR2; NGRH1; NGRL3; Nogo receptor-like 3; Nogo-66 receptor homolog 1; Nogo-66 receptor-related protein 2; R4RL2; reticulon 4 receptor like 2; reticulon 4 receptor-like 2; Reticulon-4 receptor-like 2; RTN4RL2
Gene Symbols: RTN4RL2
Molecular weight: 46,106 Da
Basal Isoelectric point: 7.58  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein