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CDC25A
Tyrosine protein phosphatase which functions as a dosage-dependent inducer of mitotic progression. Directly dephosphorylates CDK1 and stimulates its kinase activity. Also dephosphorylates CDK2 in complex with cyclin E, in vitro. Belongs to the MPI phosphatase family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: EC 3.1.3.48; Motility/polarity/chemotaxis; Protein phosphatase, dual-specificity |
| Chromosomal Location of human Ortholog: 3p21.31 |
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Cellular Component:
cytoplasm; cytosol; nucleoplasm; nucleus
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Molecular Function:
phosphoprotein phosphatase activity; protein binding; protein kinase binding; protein tyrosine phosphatase activity; protein-folding chaperone binding
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Biological Process:
cell division; cell population proliferation; cellular response to UV; G1/S transition of mitotic cell cycle; G2/M transition of mitotic cell cycle; positive regulation of G2/M transition of mitotic cell cycle; positive regulation of G2/MI transition of meiotic cell cycle; protein dephosphorylation; regulation of cyclin-dependent protein serine/threonine kinase activity; response to radiation
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Reference #:
P30304
(UniProtKB)
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Alt. Names/Synonyms: CDC25A; CDC25A2; cell division cycle 25 homolog A (S. pombe); cell division cycle 25A; Dual specificity phosphatase Cdc25A; M-phase inducer phosphatase 1; MPIP1
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Gene Symbols: CDC25A
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Molecular weight:
59,087 Da
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Basal Isoelectric point:
6.49
Predict pI for various phosphorylation states
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CST Pathways:
G1/S Checkpoint
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G2/M DNA Damage Checkpoint
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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