RARRES3 Exhibits both phospholipase A1/2 and acyltransferase activities. Shows phospholipase A1 (PLA1) and A2 (PLA2), catalyzing the calcium-independent release of fatty acids from the sn-1 or sn-2 position of glycerophospholipids. For most substrates, PLA1 activity is much higher than PLA2 activity. Shows O-acyltransferase activity, catalyzing the transfer of a fatty acyl group from glycerophospholipid to the hydroxyl group of lysophospholipid. Shows N-acyltransferase activity, catalyzing the calcium-independent transfer of a fatty acyl group at the sn-1 position of phosphatidylcholine (PC) and other glycerophospholipids to the primary amine of phosphatidylethanolamine (PE), forming N-acylphosphatidylethanolamine (NAPE), which serves as precursor for N-acylethanolamines (NAEs). Promotes keratinocyte differentiation via activation of TGM1. Belongs to the H-rev107 family. Widely expressed. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Cell cycle regulation; EC 3.1.1.-
Chromosomal Location of Human Ortholog: 11q12.3
Cellular Component:  cytosol; integral component of membrane
Molecular Function:  N-acyltransferase activity; phospholipase A1 activity; phospholipase A2 activity; protein binding
Biological Process:  lipid catabolic process; N-acylphosphatidylethanolamine metabolic process; negative regulation of cell proliferation; phosphatidylethanolamine acyl-chain remodeling; phospholipid metabolic process
Reference #:  Q9UL19 (UniProtKB)
Alt. Names/Synonyms: HRAS-like suppressor 4; HRASLS4; HRSL4; MGC8906; Phospholipase A and acyltransferase 4; phospholipase A/acyltransferase-4; PLA1/2-3; PLAAT-4; PLAAT4; PLAT4; RAR-responsive protein TIG3; RARRES3; retinoic acid receptor responder (tazarotene induced) 3; retinoic acid receptor responder 3; Retinoic acid receptor responder protein 3; retinoic acid-inducible gene 1; Retinoid-inducible gene 1 protein; RIG1; Tazarotene-induced gene 3 protein; TIG3
Gene Symbols: RARRES3
Molecular weight: 18,179 Da
Basal Isoelectric point: 8.78  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein