FOXN1 Transcriptional regulator which regulates the development, differentiation, and function of thymic epithelial cells (TECs) both in the prenatal and postnatal thymus. Acts as a master regulator of the TECs lineage development and is required from the onset of differentiation in progenitor TECs in the developing fetus to the final differentiation steps through which TECs mature to acquire their full functionality. Regulates, either directly or indirectly the expression of a variety of genes that mediate diverse aspects of thymus development and function, including MHC Class II, DLL4, CCL25, CTSL, CD40 and PAX1. Regulates the differentiation of the immature TECs into functional cortical TECs (cTECs) and medullary TECs (mTECs). Essential for maintenance of mTECs population in the postnatal thymus. Involved in the morphogenesis and maintenance of the three-dimensional thymic microstructure which is necessary for a fully functional thymus. Plays an important role in the maintenance of hematopoiesis and particularly T lineage progenitors within the bone marrow niche with age. Essential for the vascularization of the thymus anlage. Promotes the terminal differentiation of epithelial cells in the epidermis and hair follicles, partly by negatively regulating the activity of protein kinase C. Plays a crucial role in the early prenatal stages of T-cell ontogeny. Expressed in thymus. Note: This description may include information from UniProtKB.
Protein type: Cell development/differentiation; DNA-binding; Transcription factor
Chromosomal Location of Human Ortholog: 11 B5|11 46.74 cM
Cellular Component:  nucleus
Molecular Function:  DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; sequence-specific DNA binding
Biological Process:  blood vessel morphogenesis; cell differentiation; cell proliferation; epidermis development; epithelial cell proliferation; hair follicle development; hemopoiesis; keratinocyte differentiation; lymphocyte homeostasis; lymphoid lineage cell migration into thymus; multicellular organism development; nail development; positive regulation of epithelial cell differentiation; positive regulation of hair follicle development; positive regulation of transcription by RNA polymerase II; regulation of gene expression; regulation of positive thymic T cell selection; regulation of T cell differentiation in thymus; regulation of transcription, DNA-templated; T cell homeostasis; T cell lineage commitment; thymus development; thymus epithelium morphogenesis
Reference #:  Q61575 (UniProtKB)
Alt. Names/Synonyms: D11Bhm185e; Fkh19; forkhead box N1; Forkhead box protein N1; Foxn1; Hepatocyte nuclear factor 3 forkhead homolog 11; HFH-11; Hfh11; HNF-3/forkhead homolog 11; MGC124316; MGC124317; nu; nude; OTTMUSP00000000197; Whn; Winged-helix transcription factor nude
Gene Symbols: Foxn1
Molecular weight: 69,245 Da
Basal Isoelectric point: 5.67  Predict pI for various phosphorylation states
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FOXN1

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein