PHC3 Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. 7 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Transcription regulation
Chromosomal Location of Human Ortholog: 2q24
Cellular Component:  nucleus; PcG protein complex; PRC1 complex
Molecular Function:  zinc ion binding
Reference #:  ENSRNOP00000012758 (Ensembl)
Alt. Names/Synonyms: Phc3; polyhomeotic homolog 3; polyhomeotic homolog 3 (Drosophila); polyhomeotic like 3
Gene Symbols: Phc3
Molecular weight: 105,734 Da
Basal Isoelectric point: 6.23  Predict pI for various phosphorylation states
Select Structure to View Below

PHC3

Protein Structure Not Found.


Cross-references to other databases:  BioGPS  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein