PSMB4
Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). SMAD1/OAZ1/PSMB4 complex mediates the degradation of the CREBBP/EP300 repressor SNIP1. Belongs to the peptidase T1B family. Note: This description may include information from UniProtKB.
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Protein type: Cell cycle regulation; Cytoskeletal; EC 3.4.25.1; Protease; Proteasome complex |
Chromosomal Location of rat Ortholog: 2q34 |
Cellular Component:
ciliary basal body; cytoplasm; mitochondrion; nucleoplasm; nucleus; proteasome complex; proteasome core complex; proteasome core complex, beta-subunit complex
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Molecular Function:
lipopolysaccharide binding
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Biological Process:
negative regulation of inflammatory response to antigenic stimulus; proteasomal protein catabolic process; proteolysis involved in protein catabolic process
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Reference #:
P34067
(UniProtKB)
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Alt. Names/Synonyms: Macropain beta chain; Multicatalytic endopeptidase complex beta chain; proteasome (prosome, macropain) subunit, beta type 4; Proteasome beta chain; Proteasome chain 3; Proteasome subunit beta type-4; PSB4; Psmb4; RN3
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Gene Symbols: Psmb4
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Molecular weight:
29,197 Da
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Basal Isoelectric point:
6.45
Predict pI for various phosphorylation states
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