HSF1 a transcription factor that specifically binds heat shock promoter elements (HSE) and activates transcription. Induced in response to heat, heavy metals, and oxidative stress. In higher eukaryotes, HSF is unable to bind to HSEs unless the cells are stressed. Becomes phosphorylated in response to stress, forming homotrimers that bind DNA and activate transcription. Phosphorylation by PLK1 enhances nuclear translocation, and phosphorylation by CaMKII enhances transactivation. Phosphorylation by GSK3 and ERK1 induces binding by 14-3-3 and sequestration in the cytoplasm. In addition, during attenuation from the heat shock response, HSF1 is repressed by direct binding of Hsp70, HSP40, and HSF binding protein 1 (HSBP1). Four alternatively spliced isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Transcription factor
Chromosomal Location of Human Ortholog: 8q24.3
Cellular Component:  centrosome; condensed chromosome kinetochore; cytoplasm; cytosol; euchromatin; heterochromatin; kinetochore; mitotic spindle pole; nuclear stress granule; nucleoplasm; nucleus; perinuclear region of cytoplasm; PML body; pronucleus; ribonucleoprotein complex
Molecular Function:  chromatin DNA binding; DNA binding; DNA-binding transcription factor activity, RNA polymerase II-specific; DNA-binding transcription repressor activity, RNA polymerase II-specific; heat shock protein binding; Hsp90 protein binding; identical protein binding; promoter-specific chromatin binding; protein binding; protein heterodimerization activity; protein kinase binding; protein self-association; RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding; RNA polymerase II proximal promoter sequence-specific DNA binding; sequence-specific DNA binding; sequence-specific single stranded DNA binding; STAT family protein binding; translation elongation factor binding
Biological Process:  cellular protein-containing complex assembly; cellular response to angiotensin; cellular response to cadmium ion; cellular response to copper ion; cellular response to diamide; cellular response to estradiol stimulus; cellular response to gamma radiation; cellular response to heat; cellular response to hydrogen peroxide; cellular response to L-glutamine; cellular response to lipopolysaccharide; cellular response to nitroglycerin; cellular response to potassium ion; cellular response to sodium arsenite; cellular response to unfolded protein; defense response; DNA repair; embryonic placenta development; embryonic process involved in female pregnancy; female meiotic nuclear division; MAPK cascade; mRNA processing; mRNA transcription; mRNA transport; negative regulation of cardiac muscle cell apoptotic process; negative regulation of cell proliferation; negative regulation of double-strand break repair via nonhomologous end joining; negative regulation of inclusion body assembly; negative regulation of neuron death; negative regulation of transcription by RNA polymerase II; negative regulation of tumor necrosis factor production; positive regulation of apoptotic DNA fragmentation; positive regulation of cell proliferation; positive regulation of cold-induced thermogenesis; positive regulation of cysteine-type endopeptidase activity involved in apoptotic process; positive regulation of inclusion body assembly; positive regulation of microtubule binding; positive regulation of mitotic cell cycle; positive regulation of mRNA polyadenylation; positive regulation of multicellular organism growth; positive regulation of transcription by RNA polymerase II; positive regulation of transcription from RNA polymerase II promoter in response to heat stress; positive regulation of tyrosine phosphorylation of STAT protein; protein homooligomerization; protein homotrimerization; regulation of cellular response to heat; regulation of protein heterodimerization activity; response to activity; response to hypobaric hypoxia; response to psychosocial stress; response to testosterone; spermatogenesis
Reference #:  Q00613 (UniProtKB)
Alt. Names/Synonyms: Heat shock factor protein 1; Heat shock transcription factor 1; HSF 1; HSF1; HSTF 1; HSTF1
Gene Symbols: HSF1
Molecular weight: 57,260 Da
Basal Isoelectric point: 5.02  Predict pI for various phosphorylation states
CST Pathways:  SAPK/JNK Signaling Cascades
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene