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HIP14
Palmitoyltransferase specific for a subset of neuronal proteins, including SNAP25, DLG4/PSD95, GAD2, SYT1 and HTT. May be involved in the sorting or targeting of critical proteins involved in the initiating events of endocytosis at the plasma membrane. May play a role in Mg(2+) transport. Belongs to the DHHC palmitoyltransferase family. AKR/ZDHHC17 subfamily. Expressed in all brain regions. Expression is highest in the cortex, cerebellum, occipital lobe and caudate and lowest in the spinal cord. Expression is also seen in testis, pancreas, heart and kidney. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: EC 2.3.1.225; Membrane protein, integral; Membrane protein, multi-pass; Transferase; Tumor suppressor |
| Chromosomal Location of rat Ortholog: 7q22 |
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Cellular Component:
cell projection; Golgi apparatus; Golgi membrane; Golgi-associated vesicle membrane; intracellular membrane-bounded organelle; presynaptic membrane
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Molecular Function:
identical protein binding; palmitoyltransferase activity; protein-cysteine S-myristoyltransferase activity; protein-cysteine S-palmitoyltransferase activity; protein-cysteine S-stearoyltransferase activity; signaling receptor binding
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Biological Process:
axonogenesis; lipoprotein transport; peptidyl-L-cysteine S-palmitoylation; positive regulation of I-kappaB kinase/NF-kappaB signaling; protein palmitoylation; regulation of ERK1 and ERK2 cascade; regulation of neurotrophin TRK receptor signaling pathway; regulation of programmed cell death
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Reference #:
E9PTT0
(UniProtKB)
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Alt. Names/Synonyms: Acyltransferase ZDHHC17; HIP14; Membrane-associated DHHC17 zinc finger protein; Palmitoyltransferase ZDHHC17; ZDH17; Zdhhc17; Zinc finger DHHC domain-containing protein 17; zinc finger, DHHC domain containing 17; zinc finger, DHHC-type containing 17
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Gene Symbols: Zdhhc17
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Molecular weight:
71,319 Da
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Basal Isoelectric point:
7.29
Predict pI for various phosphorylation states
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